Evidence map›Paper›PMID 30538480›Full record

ArticleNeuropsychiatric disease and treatment2018

Aberrantly expressed long noncoding RNAs and genes in Parkinson's disease.

Yong Zhou, Chengzhi Gu, Jia Li, Lianhai Zhu, Guoxiang Huang, Jie Dai, Huaiyu Huang

Open access · goldAbstract read
In one paragraph

Article in Neuropsychiatric disease and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Downregulation of the Long Non-Coding RNALife (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Berberine Attenuates MPPNeurochemical research · 2021
    Article
  10. Article
  11. Review
  12. LncRNAs as putative biomarkers and therapeutic targets for Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Review
  13. Article
  14. Review
  15. Long Non-coding RNAs in Parkinson's Disease.Neurochemical research · 2021
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yong ZhouDepartment of Neurology, The Second Affiliated Hospital of Nantong University, The First People's Hospital of Nantong, Nantong, China, huanghuaiyu99@163.com.
Chengzhi GuDepartment of Neurology, The Second Affiliated Hospital of Nantong University, The First People's Hospital of Nantong, Nantong, China, huanghuaiyu99@163.com.
Jia LiDepartment of Neurology, The Second Affiliated Hospital of Nantong University, The First People's Hospital of Nantong, Nantong, China, huanghuaiyu99@163.com.
Lianhai ZhuDepartment of Neurology, The Second Affiliated Hospital of Nantong University, The First People's Hospital of Nantong, Nantong, China, huanghuaiyu99@163.com.
Guoxiang HuangDepartment of Neurology, The Second Affiliated Hospital of Nantong University, The First People's Hospital of Nantong, Nantong, China, huanghuaiyu99@163.com.
Jie DaiDepartment of Neurology, The Second Affiliated Hospital of Nantong University, The First People's Hospital of Nantong, Nantong, China, huanghuaiyu99@163.com.
Huaiyu HuangDepartment of Neurology, The Second Affiliated Hospital of Nantong University, The First People's Hospital of Nantong, Nantong, China, huanghuaiyu99@163.com.
Nantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeParkinson's disease (PD) is a common neurodegenerative movement disorder, but the pathogenesis remains elusive. This study was aimed to explore key genes and long noncoding RNAs (lncRNAs) associated with PD. MATERIALS AND

methodsThree patients with PD and three normal controls were enrolled in the present study from July 12, 2017, to August 29, 2017. RNA sequencing and bioinformatics analysis were performed to obtain differentially expressed micro RNAs (DEmRNAs) and lncRNAs (DElncRNAs) between patients with PD and normal controls. PD-specific protein-protein interaction networks were constructed. DEmRNAs transcribed within a 100 kb window upstream or downstream of DElncRNAs were searched, which were defined as

resultsA total of 857 DEmRNAs and 77 DElncRNAs were obtained between PD and normal controls. Natural killer cell-mediated cytotoxicity was a significantly enriched pathway in PD. ERBB2, HSPB1, and MYC were three hub proteins of PD-specific protein-protein interaction network. LOC105378701-

conclusionThis present study identified key genes and lncRNAs associated with PD, which will provide new clues for exploring the pathogenesis and developing potential biomarkers of PD.

Indexed as

bioinformatics analysismRNAprotein–protein interaction networkRNA-sequencing

Identifiers

PMID30538480
PMCPMC6257365
OpenAlexW2901712339

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.