ArticleNeuropsychiatric disease and treatment2018
Brain structural networks and connectomes: the brain-obesity interface and its impact on mental health.
Article in Neuropsychiatric disease and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Introducing Structural Reliance: A New Method to Assess Structure-Function Coupling in the Brain.Human brain mapping · 2026Article
- Weight matters: Higher BMI is associated with changes in the brain connectome in health and depression.Neuroscience applied · 2026Article
- Interaction between baseline BMI and baseline disease severity predicts greater improvement in negative symptoms in first-episode schizophrenia.European archives of psychiatry and clinical neuroscience · 2024Article
- Early life factors and structural brain network in children with overweight/obesity: The ActiveBrains project.Pediatric research · 2024Article
- Diffusion tensor imaging findings in the hunger and satiety centers of the brain after bariatric surgery: a preliminary study.Irish journal of medical science · 2024Article
- Effect of Preadolescents' Obesity on Inhibitory Control During Stop-Signal Task: A Functional EEG Network Study.IEEE open journal of engineering in medicine and biology · 2024Article
- The Developing Brain: Considering the Multifactorial Effects of Obesity, Physical Activity & Mental Wellbeing in Childhood and Adolescence.Children (Basel, Switzerland) · 2022Review
- Association of body mass index and its classifications with gray matter volume in individuals with a wide range of body mass index group: A whole-brain magnetic resonance imaging study.Frontiers in human neuroscience · 2022Article
- Inter-individual body mass variations relate to fractionated functional brain hierarchies.Communications biology · 2021Article
- Disrupted white matter connectivity and organization of brain structural connectomes in tuberous sclerosis complex patients with neuropsychiatric disorders using diffusion tensor imaging.Magma (New York, N.Y.) · 2021Article
- Genetic Influence Underlying Brain Connectivity Phenotype: A Study on Two Age-Specific Cohorts.Frontiers in genetics · 2021Article
- Bypassing TBI: Metabolic Surgery and the Link between Obesity and Traumatic Brain Injury-a Review.Obesity surgery · 2020Review
- Depressive and anxiety symptoms and suicidality in adolescent and young adult females with moderate to severe obesity before and after weight loss surgery.Clinical obesity · 2020Article
- Article
- The Dynamics of Functional Brain Networks Associated With Depressive Symptoms in a Nonclinical Sample.Frontiers in neural circuits · 2020Article
- Recent Advances in the Neurobiology of Altered Motivation Following Bariatric Surgery.Current psychiatry reports · 2019Review
- Pain-Related Anxiety among Adults with Obesity and Chronic Pain: Relations with Pain, Opioid Misuse, and Mental Health.Behavioral medicine (Washington, D.C.)Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeObesity is a complex and multifactorial disease identified as a global epidemic. Convergent evidence indicates that obesity differentially influences patients with neuropsychiatric disorders providing a basis for hypothesizing that obesity alters brain structure and function associated with the brain's propensity toward disturbances in mood and cognition. Herein, we characterize alterations in brain structures and networks among obese subjects (ie, body mass index [BMI] ≥30 kg/m PATIENTS AND
methodsWe obtained noninvasive diffusion tensor imaging and generalized q-sampling imaging scans of 20 obese subjects (BMI=37.9±5.2 SD) and 30 non-obese controls (BMI=22.6±3.4 SD). Graph theoretical analysis and network-based statistical analysis were performed to assess structural and functional differences between groups. We additionally assessed for correlations between diffusion indices, BMI, and anxiety and depressive symptom severity (ie, Hospital Anxiety and Depression Scale total score).
resultsThe diffusion indices of the posterior limb of the internal capsule, corona radiata, and superior longitudinal fasciculus were significantly lower among obese subjects when compared with controls. Moreover, obese subjects were more likely to report anxiety and depressive symptoms. There were fewer structural network connections observed in obese subjects compared with non-obese controls. Topological measures of clustering coefficient (C), local efficiency (E
conclusionWe extend knowledge further by delineating structural interconnectivity alterations within and across brain regions that are adversely affected in individuals who are obese.
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