ArticleInternational journal of nanomedicine2018
Electrospun nanofiber blend with improved mechanical and biological performance.
Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Advanced Antibacterial Nanocomposite Fibers for Biomedical Applications.Pharmaceutics · 2026Article
- Single-Step Extrusion Printing of Microgrooved Annulus Fibrosus Scaffolds via Patterned Nozzles.Journal of functional biomaterials · 2026Article
- Optimizing Gelatin Methacryloyl for Craniofacial Muscle Regeneration: Material Design and Application.Gels (Basel, Switzerland) · 2025Article
- Decoupling Bioactivity and Processability: RGD Click-Functionalized Coatings for a 3D-Printed PCL Scaffold.Biomacromolecules · 2025Article
- Cardiac Tissue Engineering for Translational Cardiology: From In Vitro Models to Regenerative Therapies.Bioengineering (Basel, Switzerland) · 2025Review
- The wound healing effect of polycaprolactone-chitosan scaffold coated with a gel containing Zataria multiflora Boiss. volatile oil nanoemulsions.BMC complementary medicine and therapies · 2024Article
- Electrospun PVA Fibers for Drug Delivery: A Review.Polymers · 2023Review
- Hydrogel-Impregnated Self-Oxygenating Electrospun Scaffolds for Bone Tissue Engineering.Bioengineering (Basel, Switzerland) · 2023Article
- Nanoscale β-TCP-Laden GelMA/PCL Composite Membrane for Guided Bone Regeneration.ACS applied materials & interfaces · 2023Article
- In Situ Electrospinning of "Dry-Wet" Conversion Nanofiber Dressings for Wound Healing.Marine drugs · 2023Article
- Marine Gelatin-Methacryloyl-Based Hydrogels as Cell Templates for Cartilage Tissue Engineering.Polymers · 2023Article
- Nude and Modified Electrospun Nanofibers, Application to Air Purification.Nanomaterials (Basel, Switzerland) · 2023Review
- Advanced functional nanofibers: strategies to improve performance and expand functions.Frontiers of optoelectronics · 2022Review
- Engineering approaches for cardiac organoid formation and their characterization.Translational research : the journal of laboratory and clinical medicine · 2022Review
- Article
- Tri-Layered and Gel-Like Nanofibrous Scaffolds with Anisotropic Features for Engineering Heart Valve Leaflets.Advanced healthcare materials · 2022Article
- Influence of Fish Scale-Based Hydroxyapatite on Forcespun Polycaprolactone Fiber Scaffolds.ACS omega · 2022Article
- Electrospun Methacrylated Gelatin/Poly(L-Lactic Acid) Nanofibrous Hydrogel Scaffolds for Potential Wound Dressing Application.Nanomaterials (Basel, Switzerland) · 2021Article
- In Vitro Biological Evaluation of a Fabricated Polycaprolactone/Pomegranate Electrospun Scaffold for Bone Regeneration.ACS omega · 2021Article
- Electrospun hydrogels for dynamic culture systems: advantages, progress, and opportunities.Biomaterials science · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
backgroundHere, electrospun fibers based on a blend of polycaprolactone (PCL), poly(ethylene glycol) (PEG), and gelatin methacryloyl (GelMA) were developed. The careful choice of this polymer combination allowed for the preparation of a biomaterial that preserved the mechanical strength of PCL, while at the same time improving the hydrophilicity of the blended material and human osteoblast maturation.
methodsThe morphology, chemical structure, wettability, and mechanical properties before and after UV photocrosslinking were evaluated. Furthermore, human osteoblasts (hFOB) were cultivated for up to 21 days on the scaffolds, and their potential to upregulate cell proliferation, alkaline phosphatase (ALP) activity, and calcium deposition were investigated.
resultsContact angle measurement results showed that the developed scaffolds presented hydrophilic properties after PEG and GelMA incorporation before (25°) and after UV photocross-linking (69°) compared to pure PCL (149°). PCL:PEG:GelMA-UV displayed a slight increase in mechanical strength (elastic modulus ~37 MPa) over PCL alone (~33 MPa). Normally, an increase in strength of fibers leads to a decrease in elongation at break, due to the material becoming less deformable and stiffer, thus leading to breaks at low strain. This behavior was observed by comparing PCL (elongation at break ~106%) and PCL:PEG:GelMA-UV (~50%). Moreover, increases in ALP activity (10-fold at day 14) and calcium deposition (1.3-fold at day 21) by hFOBs were detected after PEG and GelMA incorporation after UV photocross-linking compared to pure PCL. Ultrathin and hydrophilic fibers were obtained after PEG and GelMA incorporation after UV photocrosslinking, but the strength of PCL was maintained. Interestingly, those ultrathin fiber characteristics improved hFOB functions.
conclusionThese findings appear promising for the use of these electrospun scaffolds, based on the combination of polymers used here for numerous orthopedic applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.