Evidence map›Paper›PMID 30538463›Full record

ArticleInternational journal of nanomedicine2018

Mechanism research on a bioactive resveratrol- PLA-gelatin porous nano-scaffold in promoting the repair of cartilage defect.

Fei Yu, Ming Li, Zhipeng Yuan, Feng Rao, Xingxing Fang, Baoguo Jiang, Yongqiang Wen, Peixun Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 62 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Fei YuDepartment of Orthopedics and Trauma, Peking University People's Hospital, Beijing, China, zhangpeixun@tom.com.
Ming LiDepartment of Orthopedics and Trauma, Peking University People's Hospital, Beijing, China, zhangpeixun@tom.com.
Zhipeng YuanSchool of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, China, wyq_wen@ustb.edu.cn.
Feng RaoDepartment of Orthopedics and Trauma, Peking University People's Hospital, Beijing, China, zhangpeixun@tom.com.
Xingxing FangDepartment of Orthopedics and Trauma, Peking University People's Hospital, Beijing, China, zhangpeixun@tom.com.
Baoguo JiangDepartment of Orthopedics and Trauma, Peking University People's Hospital, Beijing, China, zhangpeixun@tom.com.
Yongqiang WenSchool of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, China, wyq_wen@ustb.edu.cn.
Peixun ZhangDepartment of Orthopedics and Trauma, Peking University People's Hospital, Beijing, China, zhangpeixun@tom.com.
Peking University · CNUniversity of Science and Technology Beijing · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundArticular cartilage defects are difficult to treat, but drug-loaded tissue engineering scaffolds provide a possible treatment option for these types of injuries. PURPOSE: In this study, we designed a bioactive resveratrol-PLA-gelatin porous nano-scaffold using electrospinning, freeze drying, and uniform dispersion techniques to repair articular cartilage defects, and then investigated the possible mechanism behind the successful repair.

methodsWe established an articular cartilage defect rat model with a 2 mm diameter wound in the middle of the knee joint femoral condyle non-weight-bearing area, with a depth reaching the full thickness of the subchondral bone. Postmodel specimens and micro computed tomography (CT) were used to observe any macroscopic morphological changes in the articular cartilage and subchondral bone, whereas multiple staining methods were used to observe all microcosmic morphological changes. Gross scores and Mankin scores were used to evaluate the repair condition. Immunohistochemical staining was employed to detect protein expression.

resultsWhen the repair included the resveratrol-PLA-gelatin porous nano-scaffold, the repaired cartilage and subchondral bone were in better condition. The expression levels of SIRT1, type II collagen, and PI3K/AKT signaling pathway-related proteins (AKT, VEGF, PTEN, Caspase 9, and MMP13) changed significantly. The expression levels of SIRT1,AKT and type II collagen proteins increased significantly, while the expression levels of VEGF, PTEN, Caspase9 and MMP13 proteins decreased significantly compared with the repair included blank porous PLA-gelatin nano-scaffold and without scaffold.

conclusionWe designed a bioactive resveratrol-PLA-gelatin porous nano-scaffold with better performance, which promoted the repair of cartilage injury as a whole, and explained its possible mechanism in accelerating cartilage repair via the PI3K/AKT signaling pathway.

Indexed as

AnimalsCartilage, ArticularDrug LiberationFemaleGelatinKnee JointNanoparticlesPolyestersRats, Sprague-DawleyResveratrolTissue ScaffoldsWound HealingX-Ray MicrotomographyGelatinPolyesterspoly(lactide)Resveratrolcartilage defectnano-scaffoldPI3K/AKT signalingPLA—gelatinresveratrol

Identifiers

PMID30538463
PMCPMC6255055
OpenAlexW2900464235

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.