ArticleInternational journal of chronic obstructive pulmonary disease
Impact of COPD on prognosis of lung cancer: from a perspective on disease heterogeneity.
Article in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- The role of COPD in survival of NSCLC patients receiving immune checkpoint inhibitors: A meta-analysis.Biomolecules & biomedicine · 2025Pooled it
- Lung Cancer Risk in US Adults with COPD: A Systematic Review and Meta-Analysis.International journal of chronic obstructive pulmonary disease · 2025Pooled it
- [Study on the Benefit of Postoperative Exercise Rehabilitation in Patients with Lung Cancer Complicated with Chronic Obstructive Pulmonary Disease].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2022Trial
- Effects of Inhaled Corticosteroids and Long-Acting β2-Agonists on Efferocytosis and Inflammatory Cell Survival: An In Vitro Study Relevant to COPD and Lung Cancer.International journal of molecular sciences · 2026Article
- Preoperative Pulmonary Rehabilitation and Perioperative Outcomes in High-Risk COPD Patients Undergoing Lung Cancer Surgery: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- The impact of chest computed tomography-defined emphysema on extrapulmonary metastases in patients with lung cancer.BMC medical imaging · 2026Article
- Development and Internal Validation of a Nutrition-Related Indicator-Based Prediction Model for in-Hospital Mortality in Hospitalized Patients with AECOPD.International journal of chronic obstructive pulmonary disease · 2026Article
- The Multifaceted Roles of Neutrophil Death in COPD and Lung Cancer.Journal of respiratory biology and translational medicine · 2025Article
- Long-term outcomes of drainless anatomical lung resection surgery for pulmonary malignancies.Journal of cardiothoracic surgery · 2025Article
- The causal and mediation effect of chronic obstructive pulmonary disease on lung cancer subtypes: a two-sample mendelian randomization study.Cancer causes & control : CCC · 2025Article
- COPD Severity as an Independent Predictor of Long-Term Survival in Operable Lung Cancer: A Retrospective Analysis from a High-Volume Thoracic Surgery Center.International journal of chronic obstructive pulmonary disease · 2025Article
- COPD With Lung Cancer Among Older United States Adults: Prevalence, Diagnostic Timeliness, and Association With Earlier Stage Tumors.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024Article
- ASO Author Reflections: How Does Emphysema Contribute to Poor Prognosis After Lung Cancer Surgery?Annals of surgical oncology · 2024Article
- Article
- Review
- Lung Cancer in Women-Sociodemographic, Clinical and Psychological Characteristics with Comparison to Men.Journal of clinical medicine · 2024Article
- Unraveling the causality between chronic obstructive pulmonary disease and its common comorbidities using bidirectional Mendelian randomization.European journal of medical research · 2024Article
- Metabolic pathways from the gut metatranscriptome are associated with COPD and respiratory function in lung cancer patients.Frontiers in cellular and infection microbiology · 2024Article
- Inhaled medications for chronic obstructive pulmonary disease predict surgical complications and survival in stage I non-small cell lung cancer.Journal of thoracic disease · 2023Article
- International expert consensus on diagnosis and treatment of lung cancer complicated by chronic obstructive pulmonary disease.Translational lung cancer research · 2023Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCOPD is an important comorbidity of lung cancer, but the impact of COPD on the outcomes of lung cancer remains uncertain. Because both COPD and lung cancer are heterogeneous diseases, we evaluated the link between COPD phenotypes and the prognosis of different histological subtypes of lung cancer.
methodsIn this retrospective study, subjects with a newly and pathologically confirmed diagnosis of lung cancer were enrolled from patients preparing for lung cancer surgery. All participants underwent pulmonary function test (PFT). The diagnosis of COPD was based on GOLD criteria. Lung cancer subtypes and COPD phenotypes were categorized by WHO classification of lung tumors and computer quantitative analysis of PFT. The HRs were estimated by Cox regression analysis.
resultsAmong 2,222 lung cancer patients, 32.6% coexisted with COPD. After adjustment for age, sex, body mass index (BMI), smoking status, and therapy method, COPD was significantly associated with the decreased overall survival (OS) of lung cancer (HR 1.28, 95% CI 1.05-1.57). With the increased severity of COPD, the OS of lung cancer was gradually worsened (HR 1.23, 95% CI 1.08-1.39). But surgical treatment and high BMI were independent prognostic protective factors (HR 0.46, 95% CI 0.37-0.56; HR 0.96, 95% CI 0.94-0.99). Moreover, in terms of disease heterogeneity, emphysema-predominant phenotype of COPD was an independent prognostic risk factor for squamous carcinoma (HR 2.53, 95% CI 1.49-4.30). No significant relationship between COPD phenotype and lung cancer prognosis was observed among adenocarcinoma, small cell lung cancer, large cell lung cancer, and other subtype patients.
conclusionThese findings suggest that COPD, especially emphysema-predominant phenotype, is an independent prognostic risk factor for squamous carcinoma only.
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