ArticlePediatric research2019
Neonatal intermittent hypoxemia events are associated with diagnosis of bronchopulmonary dysplasia at 36 weeks postmenstrual age.
Article in Pediatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05298748 (Womb Recordings and Respiratory Control Maturation in Neonates), which is not on this map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Womb Recordings and Respiratory Control Maturation in Neonates
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Indications and timings for caffeine initiation in preterm infants.The Cochrane database of systematic reviews · 2025Pooled it
- Methylxanthines for the prevention or treatment of intermittent hypoxemia or respiratory insufficiency in late preterm infants.The Cochrane database of systematic reviews · 2024Pooled it
- Performance and safety of the PRICO closed-loop oxygen saturation targeting system in neonates: pragmatic multicentre cross-over study (TarOx Study).BMJ paediatrics open · 2024Trial
- Hypoxemia Surrounding Enteral Feeds in Preterm Infants Receiving Extended Continuous Positive Airway Pressure.Research square · 2026Article
- Prediction of bronchopulmonary dysplasia seven days after birth using respiratory and oxygenation timeseries with machine learning.Pediatric research · 2026Article
- Intermittent hypoxemia metrics enhance bronchopulmonary dysplasia severity predictions in extremely low gestational age newborns.Pediatric research · 2026Article
- Defining apnea of prematurity is messy.Pediatric research · 2026Article
- Definitions and monitoring methods for apnea in preterm infants: a scoping review.Pediatric research · 2026Article
- The Effect of Body Position on Oxygenation, Ventilation, and Diaphragmatic Workload in Infants Born Premature on Noninvasive Neurally Adjusted Ventilatory Assist.Journal of pediatrics. Clinical practice · 2026Article
- Physicians' eye-tracking in neonatal intensive care: evaluating a mechanical ventilator panel.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2026Article
- Oxidant Stress, Hyperoxia/Hypoxia and Neonatal Respiratory Disorders.Antioxidants (Basel, Switzerland) · 2025Review
- Neonatal intermittent hypoxemia events are associated with later systemic hypertension.Pediatric research · 2025Article
- Oxygenation Instability and Short-Term Morbidities Among Very-Low-Birthweight Premature Infants.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- The Role of Mesenchymal Stromal Cells in the Treatment of Bronchopulmonary Dysplasia: A Multi-Prong Approach for a Heterogeneous Disease.Comprehensive physiology · 2025Review
- Tachycardia-Desaturation Episodes in Neonatal Intensive Care Unit Patients with and without Bronchopulmonary Dysplasia.American journal of perinatology · 2025Article
- Extending Nasal Continuous Positive Airway Pressure for Preterm Infants: New Targets for an Old Device.American journal of respiratory and critical care medicine · 2025Article
- Effect of Study-Duration and Time of Day on Multichannel Sleep Study Findings in Former Preterm Infants.Children (Basel, Switzerland) · 2025Article
- Risk factors for and outcomes of intraoperative desaturation in neonates undergoing non-cardiac surgery: a retrospective study.World journal of pediatric surgery · 2025Article
- Wearable fiber-free optical sensor for continuous monitoring of neonatal cerebral blood flow and oxygenation.Pediatric research · 2024Article
- Highly comparative time series analysis of oxygen saturation and heart rate to predict respiratory outcomes in extremely preterm infants.Physiological measurement · 2024Observational
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundBronchopulmonary dysplasia (BPD) is a chronic lung disease and major pulmonary complication after premature birth. We have previously shown that increased intermittent hypoxemia (IH) events have been correlated to adverse outcomes and mortality in extremely premature infants. We hypothesize that early IH patterns are associated with the development of BPD.
methodsIH frequency, duration, and nadirs were assessed using oxygen saturation (SpO
resultsDiagnosis of BPD at 36 weeks postmenstrual age was associated with increased daily IH, longer IH duration, and a higher IH nadir. Significant differences were detected through day 7 to day 26 of life. Infants who developed BPD had lower mean SpO
conclusionsBPD was associated with more frequent, longer, and less severe IH events in addition to increased oxygen and pressure exposure within the first 26 days of life. Early IH patterns may contribute to the development of BPD or aid in identification of neonates at high risk.
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