ArticleNature communications2018
Proteasomal degradation of BRAHMA promotes Boron tolerance in Arabidopsis.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 57 citations in OpenAlex.
- Abscisic acid-regulated stability of CmABF1 and CmBRM modulates salt tolerance in chrysanthemum via epigenetic regulation ofScience advances · 2026Article
- BRAHMA represses STOP1-NRT1.1 module to control plant rhizosphere alkalization and acid stress adaptation.Nature communications · 2026Article
- Small-scale heterogeneity of soil properties in farmland affected fava beans growth through rhizosphere differential metabolites and microorganisms.Environmental microbiome · 2025Article
- Article
- Crosstalk among plant hormone regulates the root development.Plant signaling & behavior · 2024Review
- Mechanistic insights into DNA damage recognition and checkpoint control in plants.Nature plants · 2024Review
- Analogy of silicon and boron in plant nutrition.Frontiers in plant science · 2024Review
- Beyond NPK: Mineral Nutrient-Mediated Modulation in Orchestrating Flowering Time.Plants (Basel, Switzerland) · 2023Review
- Spotlight on Plant Bromodomain Proteins.Biology · 2023Review
- BRM Complex in Arabidopsis Adopts ncBAF-like Composition and Requires BRD Subunits for Assembly and Stability.International journal of molecular sciences · 2023Article
- What Can Boron Deficiency Symptoms Tell Us about Its Function and Regulation?Plants (Basel, Switzerland) · 2023Review
- RNA-binding protein MAC5A interacts with the 26S proteasome to regulate DNA damage response in Arabidopsis.Plant physiology · 2023Article
- Article
- Genome-wide identification of genes encoding SWI/SNF components in soybean and the functional characterization ofFrontiers in plant science · 2023Article
- Identification of the Karyopherin Superfamily in Maize and Its Functional Cues in Plant Development.International journal of molecular sciences · 2022Review
- Establishment of a Landscape of UPL5-Ubiquitinated on Multiple Subcellular Components of Leaf Senescence Cell inInternational journal of molecular sciences · 2022Article
- Multiple functions of SWI/SNF chromatin remodeling complex in plant-pathogen interactions.Stress biology · 2021Review
- Genome Maintenance Mechanisms at the Chromatin Level.International journal of molecular sciences · 2021Review
- BRAHMA-interacting proteins BRIP1 and BRIP2 are core subunits of Arabidopsis SWI/SNF complexes.Nature plants · 2020Article
- Unwinding BRAHMA Functions in Plants.Genes · 2020Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High levels of boron (B) induce DNA double-strand breaks (DSBs) in eukaryotes, including plants. Here we show a molecular pathway of high B-induced DSBs by characterizing Arabidopsis thaliana hypersensitive to excess boron mutants. Molecular analysis of the mutants revealed that degradation of a SWItch/Sucrose Non-Fermentable subunit, BRAHMA (BRM), by a 26S proteasome (26SP) with specific subunits is a key process for ameliorating high-B-induced DSBs. We also found that high-B treatment induces histone hyperacetylation, which increases susceptibility to DSBs. BRM binds to acetylated histone residues and opens chromatin. Accordingly, we propose that the 26SP limits chromatin opening by BRM in conjunction with histone hyperacetylation to maintain chromatin stability and avoid DSB formation under high-B conditions. Interestingly, a positive correlation between the extent of histone acetylation and DSB formation is evident in human cultured cells, suggesting that the mechanism of DSB induction is also valid in animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.