Evidence map›Paper›PMID 30538147›Full record

ArticlePediatrics2019

Neonatal Intubation Practice and Outcomes: An International Registry Study.

Elizabeth E Foglia, Anne Ades, Taylor Sawyer, Kristen M Glass, Neetu Singh, Philipp Jung, Bin Huey Quek, Lindsay C Johnston, James Barry, Jeanne Zenge and 7 more

5 registry-linked trialsAbstract readMulticenter Study
In one paragraph

Article in Pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 121 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04820101 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Dexmedetomidine for LISA Procedure in Preterm Infants: a Pilot Study

TypeinterventionalSponsorUniversity of PadovaRan2021 to 2023Enrolled40ConditionsRDSArmsDexmedetomidine
NCT05451953 nacompletednot on this mapstarted 2022, after this paper: background citation

Apneic Oxygenation to Prevent Oxygen Desaturation During Intubation in the NICU

TypeinterventionalSponsorUniversity of PennsylvaniaRan2022 to 2026Enrolled110ConditionsNeonatal Respiratory Failure, Tracheal Intubation MorbidityArmsApneic Oxygenation, Standard of Care
NCT06139809 nacompletednot on this mapstarted 2024, after this paper: background citation

The IntubAID Study - Noninvasive Positive Pressure Ventilation During Neonatal Nasal Intubation

TypeinterventionalSponsorUniversity of ZurichRan2024 to 2025Enrolled50ConditionsInfant, Newborn, Diseases, Intubation ComplicationArmsIntubation
NCT06757543 narecruitingnot on this mapstarted 2025, after this paper: background citation

A Stepped Wedge Cluster Randomised Trial Of Video Versus Direct Laryngoscopy For Intubation Of Newborn Infants

TypeinterventionalSponsorUniversity College DublinRan2025 to 2026Enrolled840ConditionsIntubation, Intubation Complications, Infant, Newborn, Infant Respiratory Distress SyndromeArmsVideo laryngoscopy, Direct laryngoscopy with standard laryngoscope
NCT07650552 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of the Association of Fentanyl and Rocuronium on First-Attempt Success Rate of Tracheal Intubation in Newborns: A Randomized Clinical Trial

TypeinterventionalSponsorUEA - Universidade Do Estado Do AmazonasRan2026 to 2029Enrolled102ConditionsInfant, Premature, Intubation, Intratracheal, Respiratory Distress Syndrome, Newborn, Apnea of PrematurityArmsRocuronium Bromide 10 MG/ML, Fentanyl 1 mcg/kg IV, single dose, administered before non-emergent tracheal intubation.
3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Comparison of laryngeal mask airway and endotracheal tube placement in neonates.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Trial
  8. Predictors of successful treatment of respiratory distress with aerosolized calfactant.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Trial
  9. Trial
  10. Nasal high-flow therapy to Optimise Stability during Intubation: the NOSI pilot trial.Archives of disease in childhood. Fetal and neonatal edition · 2023
    Trial
  11. Trial
  12. Trial
  13. Article
  14. Article
  15. Article
  16. Article
  17. Measuring the impact of introducing a new video laryngoscope on intubation success and safety among extremely low birthweight infants.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  18. Article
  19. Observational
  20. Impact of attending neonatologist presence on neonatal intubation success and adverse events: a cohort study.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article

61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Elizabeth E FogliaDivision of Neonatology, Department of Pediatrics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; foglia@email.chop.edu.
Anne AdesDivision of Neonatology, Department of Pediatrics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Taylor SawyerDepartment of Pediatrics, School of Medicine, University of Washington, Seattle, Washington.
Kristen M GlassPenn State Health Children's Hospital and Penn State College of Medicine, Hershey, Pennsylvania.
Neetu SinghDartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
Philipp JungDepartment of Pediatrics, University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany.
Bin Huey QuekKK Women's and Children's Hospital, Singapore, Singapore.
Lindsay C JohnstonDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, Yale School of Medicine, Yale University, New Haven, Connecticut.
James BarryDepartment of Pediatrics, Section of Neonatology, School of Medicine, University of Colorado, Aurora, Colorado.
Jeanne ZengeDepartment of Pediatrics, Section of Neonatology, School of Medicine, University of Colorado, Aurora, Colorado.
Ahmed MoussaDepartment of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada.
Jae H KimDivision of Neonatology, Department of Pediatrics, University of California, San Diego and Rady Children's Hospital of San Diego, San Diego, California.
Stephen D DeMeoWakeMed Health and Hospitals, Raleigh, North Carolina; and.
Natalie NapolitanoDepartments of Nursing, Respiratory Care and Neurodiagnostic Services and.
Vinay NadkarniAnesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Akira NishisakiAnesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
NEAR4NEOS Investigators

Funding

Improving the Safety of Pediatric Tracheal Intubations in ICUs with Apneic Oxygenation and Video LaryngoscopesR18HS024511 · AHRQ · CHILDREN'S HOSP OF PHILADELPHIA · PI NISHISAKI, AKIRA · 2016 to 2019
$996k
Optimizing Respiratory Function in Delivery Room Resuscitation: The INFLATE Study (INFant Lung Aeration during Transition Events)K23HD084727 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI FOGLIA, ELIZABETH · 2016 to 2020
$809k
Improving safety and quality of tracheal intubations in neonatal ICUsR21HD089151 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI NISHISAKI, AKIRA · 2017 to 2018
$470k
AHRQ HHS R18 HS024511NICHD NIH HHS K23 HD084727NICHD NIH HHS R21 HD089151
6 · The paper itself

Abstract

BACKGROUND AND

objectivesNeonatal tracheal intubation is a critical but potentially dangerous procedure. We sought to characterize intubation practice and outcomes in the NICU and delivery room (DR) settings and to identify potentially modifiable factors to improve neonatal intubation safety.

methodsWe developed the National Emergency Airway Registry for Neonates and collected standardized data for patients, providers, practices, and outcomes of neonatal intubation. Safety outcomes included adverse tracheal intubation-associated events (TIAEs) and severe oxygen desaturation (≥20% decline in oxygen saturation). We examined the relationship between intubation characteristics and adverse events with univariable tests and multivariable logistic regression.

resultsWe captured 2009 NICU intubations and 598 DR intubations from 10 centers. Pediatric residents attempted 15% of NICU and 2% of DR intubations. In the NICU, the first attempt success rate was 49%, adverse TIAE rate was 18%, and severe desaturation rate was 48%. In the DR, 46% of intubations were successful on the first attempt, with 17% TIAE rate and 31% severe desaturation rate. Site-specific TIAE rates ranged from 9% to 50% (

conclusionsWe implemented a novel multisite neonatal intubation registry and identified potentially modifiable factors associated with adverse events. Our results will inform future interventional studies to improve neonatal intubation safety.

Indexed as

InternationalityRegistriesEmergency Medical ServicesFemaleHumansInfantInfant, NewbornIntensive Care, NeonatalIntubation, IntratrachealMaleProspective StudiesTreatment Outcome

Identifiers

PMID30538147
PMCPMC6317557

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.