Evidence map›Paper›PMID 30538132›Full record

ArticleThe Journal of biological chemistry2019

The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β

Samuel Mon-Wei Yu, Pierre-Yves Jean-Charles, Dennis M Abraham, Suneet Kaur, Clarice Gareri, Lan Mao, Howard A Rockman, Sudha K Shenoy

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. The importance of myosin ubiquitination status for cardiac remodeling: USP20 has entered the chat.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Structural and functional studies of USP20 ZnF-UBP domain by NMR.Protein science : a publication of the Protein Society · 2019
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Samuel Mon-Wei YuFrom the Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27710.
Pierre-Yves Jean-CharlesFrom the Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27710.
Dennis M AbrahamFrom the Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27710.
Suneet KaurFrom the Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27710.
Clarice GareriFrom the Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27710.
Lan MaoFrom the Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27710.
Howard A RockmanFrom the Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27710.
Sudha K ShenoyFrom the Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27710 skshenoy@dm.duke.edu.
Duke Medical Center · US

Funding

Regulation of Beta-Adrenergic Receptor Signaling by S-NitrosylationP01HL075443 · NHLBI · DUKE UNIVERSITY · PI XIAO, KUNHONG · 2004 to 2019
$26.1M
MECHANISMS OF MALADAPTATION IN HEART FAILURER01HL056687 · NHLBI · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI Howard A Rockman · 1996 to 2026
$12.3M
Renal Genomics CoreP30DK096493 · NIDDK · DUKE UNIVERSITY · PI COFFMAN, THOMAS M · 2012 to 2016
$5.9M
Regulation of B-arrestin2's pro-atherogenic activity by the deubiquitinase USP20R01HL118369 · NHLBI · DUKE UNIVERSITY · PI FREEDMAN, NEIL J., SHENOY, SUDHA K · 2014 to 2017
$2.1M
TREK-1 in fibroblast differentiation and cardiac fibrosis developmentK08HL125905 · NHLBI · DUKE UNIVERSITY · PI ABRAHAM, DENNIS · 2015 to 2019
$746k
NHLBI NIH HHS K08 HL125905NHLBI NIH HHS P01 HL075443NHLBI NIH HHS R01 HL056687NHLBI NIH HHS R01 HL118369NIDDK NIH HHS P30 DK096493
6 · The paper itself

Abstract

Reversible ubiquitination of G protein-coupled receptors regulates their trafficking and signaling; whether deubiquitinases regulate myocardial β

Indexed as

Gene Expression Regulation, EnzymologicIon Channel GatingAmino Acid SubstitutionAnimalsEndopeptidasesHeart VentriclesMiceMice, KnockoutMutation, MissenseMyocardiumPhosphorylationReceptors, Adrenergic, beta-1UbiquitinationUbiquitin ThiolesteraseEndopeptidasesReceptors, Adrenergic, beta-1Ubiquitin ThiolesteraseUsp20 protein, mouseendocytosisG protein-coupled receptor (GPCR)lysosomeprotein kinase A (PKA)ubiquitylation (ubiquitination)

Identifiers

PMID30538132
PMCPMC6378982
OpenAlexW2904453581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.