Evidence map›Paper›PMID 30537997›Full record

ReviewJournal of neuroinflammation2018

Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke.

Liang Zhao, Qiutang Xiong, Creed M Stary, Omer Kamal Mahgoub, Yingze Ye, Lijuan Gu, Xiaoxing Xiong, Shengmei Zhu

Abstract readReview
In one paragraph

Review in Journal of neuroinflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Combined treatment withFrontiers in pharmacology · 2026
    Article
  8. Review
  9. The influence of depression onset timing after gastrointestinal diseases on dementia risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  10. The gut-brain connection: Inflammatory bowel disease increases risk of acute ischemic stroke.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Opioid Use and Gut Dysbiosis in Cancer Pain Patients.International journal of molecular sciences · 2024
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Liang ZhaoDepartment of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
Qiutang XiongDiabetes Research Center, Renmin Hospital of Wuhan University, Wuhan, China.
Creed M StaryDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Omer Kamal MahgoubCentral Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.
Yingze YeCentral Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.
Lijuan GuCentral Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.
Xiaoxing XiongCentral Laboratory, Renmin Hospital of Wuhan University, Wuhan, China. xiaoxingxiong@whu.edu.cn.ORCID http://orcid.org/0000-0001-6983-8547
Shengmei ZhuDepartment of Anesthesiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, China. smzhu20088@zju.edu.cn.

Funding

American Heart Association 14FTF19970029National Natural Science Foundation of China 81571147, 81870939
6 · The paper itself

Abstract

Emerging evidence suggests that gut-brain-microbiota axis (GBMAx) may play a pivotal role linking gastrointestinal and neuronal disease. In this review, we summarize the latest advances in studies of GBMAx in inflammatory bowel disease (IBD) and ischemic stroke. A more thorough understanding of the GBMAx could advance our knowledge about the pathophysiology of IBD and ischemic stroke and help to identify novel therapeutic targets via modulation of the GBMAx.

Indexed as

AnimalsBrain IschemiaGastrointestinal MicrobiomeHumansInflammatory Bowel DiseasesAdrenocorticotropic hormoneGut-brain-microbiota axisInflammatoryInflammatory bowel diseaseIschemic stroke

Identifiers

PMID30537997
PMCPMC6290529

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.