Evidence map›Paper›PMID 30537705›Full record

ReviewEuropean surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes2018

Biology of Nodal Spread in Colon Cancer: Insights from Molecular and Genetic Studies.

Pridvi Kandagatla, Lilias H Maguire, Karin M Hardiman

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pridvi KandagatlaDepartment of Surgery, Henry Ford Health System, Wayne State University, Detroit, Michigan, USA.
Lilias H MaguireDivision of Colorectal Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Karin M HardimanDivision of Colorectal Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA, kmha@med.umich.edu.

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Translational Research in GI CancerP50CA130810 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRENNER, DEAN E. · 2010 to 2016
$11.8M
University of Michigan Surgical Oncology Research Training ProgramT32CA009672 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JACQUELINE SARA JERUSS, WEIPING ZOU · 1991 to 2026
$6.0M
"Enhanced Recovery" Protocols and the Cost and Quality of Inpatient SurgeryK08AG047252 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI REGENBOGEN, SCOTT ELLIS · 2015 to 2019
$712k
Intra-tumor Heterogeneity in Colorectal Cancer Progression and Treatment ResponseK08CA190645 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARDIMAN, KARIN MARIE · 2016 to 2019
$700k
Toward More Effective "Enhanced Recovery" Protocols for Major Surgery in Older AdR03AG047860 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI REGENBOGEN, SCOTT ELLIS · 2014 to 2015
$229k
NCI NIH HHS K08 CA190645NCI NIH HHS L30 CA189003NCI NIH HHS P30 CA046592NCI NIH HHS P50 CA130810NCI NIH HHS T32 CA009672NIA NIH HHS K08 AG047252NIA NIH HHS R03 AG047860
6 · The paper itself

Abstract

Colorectal cancer (CRC) lymph node metastases are common but their genetics and the mechanism whereby these metastases occur are not well understood. Here we present recent data regarding genetic heterogeneity in primary CRCs and their metastasis. In addition, we explain the different potential models describing the mechanisms of metastasis and the data supporting them. Multiple studies have also revealed a variety of prognostic molecular markers that are associated with lymph node metastasis in CRC. A better understanding of genetic heterogeneity and the mechanisms of metastasis is critical to predicting clinical response and resistance to targeted therapy.

Indexed as

Colonic NeoplasmsDNA Copy Number VariationsGenetic HeterogeneityHumansLymphatic MetastasisMutationProto-Oncogene Proteins p21(ras)Whole Genome SequencingKRAS protein, humanProto-Oncogene Proteins p21(ras)Cancer geneticsColorectal cancerIntratumor heterogeneityLymph node metastasis

Identifiers

PMID30537705
PMCPMC6542270

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.