Evidence map›Paper›PMID 30537525›Full record

ArticlePeptides2019

Genetic loss of proadrenomedullin N-terminal 20 peptide (PAMP) in mice is compatible with survival.

Brooke C Matson, Manyu Li, Claire E Trincot, Elizabeth S Blakeney, Stephanie L Pierce, Kathleen M Caron

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Peptides, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Brooke C MatsonDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, 111 Mason Farm Road, CB 7545, Chapel Hill, NC, 27599, USA. Electronic address: brooke_matson@med.unc.edu.
Manyu LiDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, 111 Mason Farm Road, CB 7545, Chapel Hill, NC, 27599, USA. Electronic address: manyu_li@med.unc.edu.
Claire E TrincotDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, 111 Mason Farm Road, CB 7545, Chapel Hill, NC, 27599, USA.
Elizabeth S BlakeneyDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, 111 Mason Farm Road, CB 7545, Chapel Hill, NC, 27599, USA.
Stephanie L PierceDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, 111 Mason Farm Road, CB 7545, Chapel Hill, NC, 27599, USA. Electronic address: stephanie.pierce@duke.edu.
Kathleen M CaronDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, 111 Mason Farm Road, CB 7545, Chapel Hill, NC, 27599, USA. Electronic address: kathleen_caron@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Adrenomedullin Signaling at the Maternal-Fetal InterfaceR01HD060860 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Kathleen M Caron · 2009 to 2026
$4.8M
Cardiac Lymphatics in Heart FailureR01HL129086 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CARON, KATHLEEN M · 2016 to 2023
$4.1M
Compartmental Adrenomedullin Signaling in the Uterus during ImplantationF30HD085652 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MATSON, BROOKE · 2016 to 2019
$140k
NHLBI NIH HHS R01 HL129086NICHD NIH HHS F30 HD085652NICHD NIH HHS R01 HD060860
6 · The paper itself

Abstract

Adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) are small peptides derived from a common precursor, pre-proadrenomedullin. Although AM and PAMP share hypotensive effects in the cardiovascular system, the peptides also exert diverse and distinct effects on endocrine physiology, innate immunity, cytoskeletal biology and receptor signaling pathways. Tremendous knowledge has been gleaned from the study of several genetic animal models of AM deletion or overexpression, some of which also simultaneously delete the coding region for PAMP peptide. However, deletion of PAMP without concurrent deletion of AM in an animal model is not currently available for the study of PAMP function. Here, we present the generation of Adm

Indexed as

Models, AnimalSequence DeletionAdrenomedullinAnimalsFemaleGene Expression RegulationMiceMice, KnockoutMyocardiumPeptide FragmentsProtein PrecursorsSurvival AnalysisAdrenomedullinPeptide FragmentsproadrenomedullinProtein PrecursorsAdrenomedullinGenetic modelMousePAMP

Identifiers

PMID30537525
PMCPMC6362461
OpenAlexW2905538591

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.