Evidence map›Paper›PMID 30537350›Full record

ReviewXenotransplantation2018

Toward a solution for cardiac failure in the newborn.

Jeffrey L Platt, Lori J West, Richard E Chinnock, Marilia Cascalho

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Xenotransplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. The five dimensions of B cell tolerance.Immunological reviews · 2019
    Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Jeffrey L PlattDepartment of Surgery and Department of Microbiology & Immunology, University of Michigan, Ann Arbor, Michigan.
Lori J WestDepartment of Pediatrics, Department of Surgery, Department of Immunology, Alberta Transplant Institute, University of Alberta, Edmonton, Alberta, Canada.
Richard E ChinnockDepartment of Pediatrics, Loma Linda University School of Medicine, Loma Linda, California.
Marilia CascalhoDepartment of Surgery and Department of Microbiology & Immunology, University of Michigan, Ann Arbor, Michigan.
University of Michigan–Ann Arbor · USLoma Linda University · USUniversity of Alberta · CA

Funding

T cell responses and cardiac transplantation in infancyP01HL079067 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PLATT, JEFFREY L · 2005 to 2009
$6.3M
Hepatocyte xenografts for treatment of acute liver failureR01AI122369 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FOX, IRA J., PLATT, JEFFREY L · 2016 to 2020
$5.0M
Immunodeficient Pigs for Stem Cell­-Based Regenerative MedicineR01OD023138 · OD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI PIEDRAHITA, JORGE A · 2017 to 2020
$1.8M
Accommodation in TransplantationR56AI123262 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CASCALHO, MARILIA ISABEL, PLATT, JEFFREY L · 2016 to 2016
$388k
NHLBI NIH HHS P01 HL079067NIAID NIH HHS R01 AI122369NIAID NIH HHS R56 AI123262NIH HHS R01 OD023138
6 · The paper itself

Abstract

The newborn infant with severe cardiac failure owed to congenital structural heart disease or cardiomyopathy poses a daunting therapeutic challenge. The ideal solution for both might be cardiac transplantation if availability of hearts was not limiting and if tolerance could be induced, obviating toxicity of immunosuppressive therapy. If one could safely and effectively exploit neonatal tolerance for successful xenotransplantation of the heart, the challenge of severe cardiac failure in the newborn infant might be met. We discuss the need, the potential for applying neonatal tolerance in the setting of xenotransplantation and the possibility that other approaches to this problem might emerge.

Indexed as

Heart TransplantationTransplantation, HeterologousAnimalsGraft RejectionHeart Defects, CongenitalHeart FailureHumansImmunosuppression TherapyInfant, Newbornhypoplastic left heart syndromeneonatal toleranceorgan replacementxenotransplantation

Identifiers

PMID30537350
PMCPMC6365837
OpenAlexW2905143695

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.