Evidence map›Paper›PMID 30537103›Full record

ArticleMedical physics2019

Simultaneous cosegmentation of tumors in PET-CT images using deep fully convolutional networks.

Zisha Zhong, Yusung Kim, Kristin Plichta, Bryan G Allen, Leixin Zhou, John Buatti, Xiaodong Wu

Abstract read
In one paragraph

Article in Medical physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
  2. Review
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  4. Novel in-house knowledge-based automated planning system for lung cancer treated with intensity-modulated radiotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2024
    Article
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  8. Review
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  12. OSC-COFrontiers in plant science · 2023
    Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Standard SPECT myocardial perfusion estimation from half-time acquisitions using deep convolutional residual neural networks.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  19. Article
  20. Applications of artificial intelligence in oncologicAnnals of translational medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zisha ZhongDepartment of Electrical and Computer Engineering, The University of Iowa, Iowa City, IA, 52242, USA.
Yusung KimDepartment of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA.
Kristin PlichtaDepartment of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA.
Bryan G AllenDepartment of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA.
Leixin ZhouDepartment of Electrical and Computer Engineering, The University of Iowa, Iowa City, IA, 52242, USA.
John BuattiDepartment of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA.
Xiaodong WuDepartment of Electrical and Computer Engineering, The University of Iowa, Iowa City, IA, 52242, USA.

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Mark E Burkard · 2000 to 2026
$70.0M
The University of Iowa Clinical and Translational Science AwardUL1TR002537 · NCATS · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R, WINOKUR, PATRICIA · 2018 to 2022
$20.0M
Project 3: MRI Imaging of Redox Active Fe Predicts GBM Responses to Pharmacological AscorbateP01CA217797 · NCI · UNIVERSITY OF IOWA · PI BUATTI, JOHN M · 2018 to 2022
$9.6M
Graph-Based Medical Image Segmentation in 3D and 4DR01EB004640 · NIBIB · UNIVERSITY OF IOWA · PI BUATTI, JOHN M, SONKA, MILAN · 2006 to 2022
$6.1M
Quantitative Imaging to Assess Response in Cancer Therapy TrialsU01CA140206 · NCI · UNIVERSITY OF IOWA · PI BUATTI, JOHN M, CASAVANT, THOMAS L. · 2010 to 2019
$5.8M
Developing Enabling PET-CT Image Analysis Tools for Predicting Response in Radiation Cancer TherapyR21CA209874 · NCI · UNIVERSITY OF IOWA · PI WU, XIAODONG · 2016 to 2017
$365k
NCATS NIH HHS UL1 TR002537NCI NIH HHS 1R21CA209874NCI NIH HHS P01 CA217797NCI NIH HHS R21 CA209874NCI NIH HHS U01 CA140206NCI NIH HHS U01CA140206NCI NIH HHS UL1TR002537NIBIB NIH HHS R01 EB004640
6 · The paper itself

Abstract

purposeTo investigate the use and efficiency of 3-D deep learning, fully convolutional networks (DFCN) for simultaneous tumor cosegmentation on dual-modality nonsmall cell lung cancer (NSCLC) and positron emission tomography (PET)-computed tomography (CT) images.

methodsWe used DFCN cosegmentation for NSCLC tumors in PET-CT images, considering both the CT and PET information. The proposed DFCN-based cosegmentation method consists of two coupled three-dimensional (3D)-UNets with an encoder-decoder architecture, which can communicate with the other in order to share complementary information between PET and CT. The weighted average sensitivity and positive predictive values denoted as Scores, dice similarity coefficients (DSCs), and the average symmetric surface distances were used to assess the performance of the proposed approach on 60 pairs of PET/CTs. A Simultaneous Truth and Performance Level Estimation Algorithm (STAPLE) of 3 expert physicians' delineations were used as a reference. The proposed DFCN framework was compared to 3 graph-based cosegmentation methods.

resultsStrong agreement was observed when using the STAPLE references for the proposed DFCN cosegmentation on the PET-CT images. The average DSCs on CT and PET are 0.861 ± 0.037 and 0.828 ± 0.087, respectively, using DFCN, compared to 0.638 ± 0.165 and 0.643 ± 0.141, respectively, when using the graph-based cosegmentation method. The proposed DFCN cosegmentation using both PET and CT also outperforms the deep learning method using either PET or CT alone.

conclusionsThe proposed DFCN cosegmentation is able to outperform existing graph-based segmentation methods. The proposed DFCN cosegmentation shows promise for further integration with quantitative multimodality imaging tools in clinical trials.

Indexed as

Neural Networks, ComputerPositron Emission Tomography Computed TomographyCarcinoma, Non-Small-Cell LungHumansImage Processing, Computer-AssistedLung NeoplasmsTime FactorsWhole Body Imagingcosegmentationdeep learningnonsmall cell lung cancer (NSCLC)tumor contouring

Identifiers

PMID30537103
PMCPMC6527327

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.