Evidence map›Paper›PMID 30537004›Full record

ReviewExperimental dermatology2019

Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: Biological patterning and therapeutic potentials.

Weiming Qiu, Cheng-Ming Chuong, Mingxing Lei

Abstract readReview
In one paragraph

Review in Experimental dermatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Genetics of Waardenburg Syndrome in Africa: A Systematic Review.International journal of molecular sciences · 2025
    Pooled it
  2. Review
  3. Review
  4. The Impact of Sleep Quality on Skin Color.Indian dermatology online journal · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Rice (Foods (Basel, Switzerland) · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Two High-QualityInternational journal of molecular sciences · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Weiming QiuDepartment of Dermatology, Wuhan General Hospital of Chinese People's Liberation Army, Wuhan, China.
Cheng-Ming ChuongDepartment of Pathology, University of Southern California, Los Angeles, California.
Mingxing LeiIntegrative Stem Cell Center, China Medical University Hospital, China Medical University, Taichung, Taiwan.ORCID 0000-0002-4271-2714

Funding

Size regulation of skin appendagesR01AR047364 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Cheng-Ming Chuong · 2002 to 2026
$10.1M
Tissue Engineering of New Hair FormationR01AR060306 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHUONG, CHENG-MING · 2010 to 2019
$4.6M
Tissue Patterning in living skin and organ explantsR37AR060306 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Cheng-Ming Chuong · 2020 to 2026
$3.6M
Tissue mechanics in regenerative wound healing of the skinR01GM125322 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHUONG, CHENG-MING · 2018 to 2021
$1.3M
"Drug Development Center, China Medical University" from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in TaiwanNational Natural Science Foundation of China 81602782National Natural Science Foundation of Hubei Province 2016CFB348NIAMS NIH HHS R01 AR047364NIAMS NIH HHS R01 AR060306NIAMS NIH HHS R37 AR060306NIGMS NIH HHS R01 GM125322Projects Funded by China Postdoctoral Science Foundation 2016M590866
6 · The paper itself

Abstract

Skin evolves essential appendages and indispensable types of cells that synergistically insulate the body from environmental insults. Residing in the specific regions in the skin such as epidermis, dermis and hair follicle, melanocytes perform an array of vital functions including defending the ultraviolet radiation and diversifying animal appearance. As one of the adult stem cells, melanocyte stem cells in the hair follicle bulge niche can proliferate, differentiate and keep quiescence to control and coordinate tissue homeostasis, repair and regeneration. In synchrony with hair follicle stem cells, melanocyte stem cells in the hair follicles undergo cyclic activation, degeneration and resting phases, to pigment the hairs and to preserve the stem cells. Disorder of melanocytes results in severe skin problems such as canities, vitiligo and even melanoma. Here, we compare and summarize recent discoveries about melanocyte in the skin, particularly in the hair follicle. A better understanding of the physiological and pathological regulation of melanocyte and melanocyte stem cell behaviours will help to guide the clinical applications in regenerative medicine.

Indexed as

Skin PigmentationAdult Stem CellsAnimalsFeathersHair FollicleHumansHypopigmentationKeratinocytesMelanocytesSignal TransductionWound Healinghair follicle stem cellshair greyinghair regenerationmelanocyte stem cellspigmentation disorders

Identifiers

PMID30537004
PMCPMC6488374

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.