Evidence map›Paper›PMID 30536994›Full record

ReviewJournal of cellular physiology2019

The clinical impact of exosomes in cardiovascular disorders: From basic science to clinical application.

Farzaneh Ghafarian, Mehran Pashirzad, Majid Khazaei, Majid Rezayi, Seyed Mahdi Hassanian, Gordon A Ferns, Amir Avan

Abstract readReview
In one paragraph

Review in Journal of cellular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Extracellular Vesicle-Based Therapeutics for Heart Repair.Nanomaterials (Basel, Switzerland) · 2021
    Review
  9. Article
  10. New Developments in Exosomal lncRNAs in Cardiovascular Diseases.Frontiers in cardiovascular medicine · 2021
    Review
  11. Article
  12. Application of exosomes as liquid biopsy in clinical diagnosis.Signal transduction and targeted therapy · 2020
    Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Farzaneh GhafarianDepartment of Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mehran PashirzadDepartment of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Majid KhazaeiDepartment of Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID 0000-0002-7979-5699
Majid RezayiDepartment of Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID 0000-0003-1024-3906
Seyed Mahdi HassanianDepartment of Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID 0000-0002-5247-4043
Gordon A FernsBrighton & Sussex Medical School, Department of Division of Medical Education, Falmer, Brighton, Sussex, UK.
Amir AvanDepartment of Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID 0000-0002-4968-0962

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disease (CVD) is the major cause of death globally; therefore, there is a need for the identification of a valid biomarker that accurately predicts the risk of developing CVD, and novel therapeutic approaches for its treatment. Exosomes are very small extracellular vesicles containing protein, lipid, transcription factors, messenger RNAs, noncoding RNA, and nucleic acid contents that are important players in intercellular communication, and that act via long-range signals or cell-to-cell contact. The discovery of exosomes provides potential strategies for the diagnosis and treatment of CVD. In the current review, we have explored the potential impact of exosomes on cardiovascular physiology, and their therapeutic potential in cardiovascular disorders with an emphasis on the existing preclinical studies.

Indexed as

AnimalsCardiovascular DiseasesCell CommunicationExosomesExtracellular VesiclesHumansbiomarkercardiovascular diseasesexosomesnucleic acid contents

Identifiers

PMID30536994
PMCPMC13484088

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.