Evidence map›Paper›PMID 30536760›Full record

ReviewAmerican journal of hematology2019

Neutropenia in the age of genetic testing: Advances and challenges.

Elissa Furutani, Peter E Newburger, Akiko Shimamura

Abstract readReview
In one paragraph

Review in American journal of hematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Impaired myelopoiesis in congenital neutropenia: insights into clonal and malignant hematopoiesis.Hematology. American Society of Hematology. Education Program · 2021
    Article
  8. Diagnosis and therapeutic decision-making for the neutropenic patient.Hematology. American Society of Hematology. Education Program · 2021
    Article
  9. Article
  10. Gene Therapy to the Retina and the Cochlea.Frontiers in neuroscience · 2021
    Review
  11. Genetic predisposition to MDS: diagnosis and management.Hematology. American Society of Hematology. Education Program · 2019
    Article
  12. Benign ethnic neutropenia.Blood reviews · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Elissa FurutaniDana Farber and Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.ORCID 0000-0001-6345-9255
Peter E NewburgerDana Farber and Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.
Akiko ShimamuraDana Farber and Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
PATHOPHYSIOLOGY OF HUMAN BLOOD CELLST32HL007574 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI Daniel Evan Bauer · 1985 to 2026
$18.4M
Severe Chronic Neutropenia International RegistryR24AI049393 · NIAID · UNIVERSITY OF WASHINGTON · PI DALE, DAVID CHANDLER · 2004 to 2019
$10.6M
Translational Studies of Inherited Marrow Failure and Myelodysplastic SyndromesR24DK099808 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ABKOWITZ, JANIS L, EBERT, BENJAMIN LEVINE · 2013 to 2017
$8.2M
NCATS NIH HHS UL1 TR001102NHLBI NIH HHS T32 HL007574NIAID NIH HHS R24 AI049393NIDDK NIH HHS R24 DK099808
6 · The paper itself

Abstract

Identification of genetic causes of neutropenia informs precision medicine approaches to medical management and treatment. Accurate diagnosis of genetic neutropenia disorders informs treatment options, enables risk stratification, cancer surveillance, and attention to associated medical complications. The rapidly expanding genetic testing options for the evaluation of neutropenia have led to exciting advances but also new challenges. This review provides a practical guide to germline genetic testing for neutropenia.

Indexed as

Disease ManagementGene ExpressionGenetic Predisposition to DiseaseGenetic TestingGerm-Line MutationHumansLeukemiaLymphomaMass ScreeningMyelodysplastic SyndromesNeoplasm ProteinsNeutropeniaPractice Guidelines as TopicPrecision MedicineRisk AssessmentNeoplasm Proteins

Identifiers

PMID30536760
PMCPMC6380907

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.