Evidence map›Paper›PMID 30536648›Full record

Trial reportPhysiological reports2018

Effects of short-term endurance exercise on gut microbiota in elderly men.

Hirokazu Taniguchi, Kumpei Tanisawa, Xiaomin Sun, Takafumi Kubo, Yuri Hoshino, Masahito Hosokawa, Haruko Takeyama, Mitsuru Higuchi

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06153719 (The Effects of a 12-week Combined Exercise Intervention on the Gut Microbiome of Older Adults), which is not on this map. Cited by 83 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06153719 naunknown statusnot on this mapstarted 2023, after this paper: background citation

The Effects of a 12-week Combined Exercise Intervention on the Gut Microbiome of Older Adults

TypeinterventionalSponsorNottingham Trent UniversityRan2023 to 2024Enrolled80ConditionsPhysical InactivityArms12-weeks combined exercise intervention
3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Trial
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  13. Article
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  16. Late-in-life treadmill training mitigates gut microbiome imbalances and cardiovascular disease risk in mice.American journal of physiology. Gastrointestinal and liver physiology · 2026
    Article
  17. Review
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hirokazu TaniguchiDivision of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan.
Kumpei TanisawaDepartment of Physical Activity Research, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.
Xiaomin SunDepartment of Nutrition and Food Safety, School of Public Health, Xi' an Jiaotong University, Xi'an, China.
Takafumi KuboGraduate School of Sport Sciences, Waseda University, Tokorozawa, Japan.
Yuri HoshinoDepartment of Life Science and Medical Bioscience, Waseda University, Tokyo, Japan.
Masahito HosokawaDepartment of Life Science and Medical Bioscience, Waseda University, Tokyo, Japan.
Haruko TakeyamaDepartment of Life Science and Medical Bioscience, Waseda University, Tokyo, Japan.
Mitsuru HiguchiInstitute of Advanced Active Aging Research, Tokorozawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regular exercise reduces the risks for cardiovascular diseases. Although the gut microbiota has been associated with fitness level and cardiometabolic risk factors, the effects of exercise-induced gut microbiota changes in elderly individuals are unclear. This study evaluated whether endurance exercise modulates the gut microbiota in elderly subjects, and whether these changes are associated with host cardiometabolic phenotypes. In a randomized crossover trial, 33 elderly Japanese men participated in a 5-week endurance exercise program. 16S rRNA gene-based metagenomic analyses revealed that the effect of endurance exercise on gut microbiota diversity was not greater than interindividual differences, whereas changes in α-diversity indices during intervention were negatively correlated with changes in systolic and diastolic blood pressure, especially during exercise. Microbial composition analyses showed that the relative abundance of Clostridium difficile significantly decreased, whereas that of Oscillospira significantly increased during exercise as compared to the control period. The changes in these taxa were correlated with the changes in several cardiometabolic risk factors. The findings indicate that short-term endurance exercise has little effect on gut microbiota in elderly individuals, and that the changes in gut microbiota were associated with cardiometabolic risk factors, such as systolic and diastolic blood pressure, providing preliminary insight into the associations between the gut microbiota and cardiometabolic phenotypes.

Indexed as

Gastrointestinal MicrobiomeAgedBlood PressureClostridioides difficileEndurance TrainingHumansMaleMiddle AgedCardiovascular healthClostridium difficilemicrobiomeOscillospiraPICRUSt

Identifiers

PMID30536648
PMCPMC6286434

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.