ArticlePsychopharmacology2019
Nucleus accumbens dopamine increases sexual motivation in sexually satiated male rats.
Article in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Acetylcholine nicotinic receptors play a central role in the modulation of rewarding behaviors by interacting with dopamine transmission: evidence from male rat sexual behavior.Psychopharmacology · 2026Article
- Sexually-motivated song correlates with opioid- and dopamine-related gene expression in the rostral nucleus accumbens of male European starlings.Behavioural brain research · 2026Article
- Transcriptomic Profile of the Male Rat Hypothalamus and Nucleus Accumbens After Paroxetine Treatment and Withdrawal: Possible Causes of Sexual Dysfunction.Molecular neurobiology · 2025Article
- Blunted sensitivity to expected value during risky decision making in individuals with problematic pornography use.Journal of behavioral addictions · 2024Article
- Neurobiology of Pathogen Avoidance and Mate Choice: Current and Future Directions.Animals : an open access journal from MDPI · 2024Review
- The effect of aqueous extract of orchid root on the structure of ovary and hypothalamic-pituitary-gonadal hormones in polycystic ovary syndrome rat model: An experimental study.International journal of reproductive biomedicine · 2023Article
- Aging in nucleus accumbens and its impact on alcohol use disorders.Alcohol (Fayetteville, N.Y.) · 2023Review
- The endogenous cannabinoid system modulates male sexual behavior expression.Frontiers in behavioral neuroscience · 2023Review
- The nucleus accumbens dopamine increase, typically triggered by sexual stimuli in male rats, is no longer produced when animals are sexually inhibited due to sexual satiety.Psychopharmacology · 2022Article
- Dopamine D2 receptors in the nucleus accumbens modulate erectile function in a rat model of nonorganic erectile dysfunction.Andrology · 2022Article
- Immunolabeling Provides Evidence for Subregions in the Songbird Nucleus Accumbens and Suggests a Context-Dependent Role in Song in Male European Starlings (Sturnus vulgaris).Brain, behavior and evolution · 2021Article
- A Survey Exploring the Relationship Between Cannabis Use Characteristics and Sexual Function in Men.Sexual medicine · 2020Article
- Endocannabinoids Interact With the Dopaminergic System to Increase Sexual Motivation: Lessons From the Sexual Satiety Phenomenon.Frontiers in behavioral neuroscience · 2019Article
- Low Daytime Light Intensity Disrupts Male Copulatory Behavior, and Upregulates Medial Preoptic Area Steroid Hormone and Dopamine Receptor Expression, in a Diurnal Rodent Model of Seasonal Affective Disorder.Frontiers in behavioral neuroscience · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
rationaleThe influence of the main dopaminergic brain regions controlling copulation, the medial preoptic area (mPOA) and the nucleus accumbens (NAcc), on male rat sexual behavior expression has not been fully established.
objectiveThis work analyzes the sexual effects of dopamine (DA) receptor activation in the mPOA or the NAcc of sexually active male rats, with an intact (sexually experienced) or a reduced (sexually exhausted) sexual motivation.
methodsThe non-specific DA receptor agonist apomorphine and the D2-like receptor agonist quinpirole were infused into the mPOA or the NAcc of sexually experienced or sexually exhausted male rats and their sexual behavior recorded.
resultsDA receptor activation neither in the mPOA nor in the NAcc modified the copulatory behavior of sexually experienced male rats. DA receptor stimulation in the NAcc, but not in the mPOA, reversed the characteristic sexual inhibition of sexually satiated rats, and D2-like receptors were found to participate in this effect.
conclusionThe optimal sexual performance of sexually experienced male rats cannot be further improved by DA receptor activation at either brain region. In sexually satiated rats, which are sexually inhibited and have a diminished sexual motivation, NAcc DA receptor stimulation appears to play a key role in their capacity to respond to a motivational significant stimulus, the receptive female, with the participation of D2-like receptors. Activation of DA receptors with the same drug, at the same dose and in the same brain region, produces different effects on copulatory behavior that depend on the animal's sexual motivational state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.