Evidence map›Paper›PMID 30536017›Full record

ArticleObesity surgery2019

Overall and Estrogen Receptor-Positive Breast Cancer Incidences Are Decreased Following Bariatric Surgery.

Taryn E Hassinger, J Hunter Mehaffey, Robert B Hawkins, Bruce D Schirmer, Peter T Hallowell, Anneke T Schroen, Shayna L Showalter

Abstract read
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In one paragraph

Article in Obesity surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  4. Review
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  11. Breast Cancer Population Attributable Risk Proportions Associated with Body Mass Index and Breast Density by Race/Ethnicity and Menopausal Status.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Taryn E HassingerDepartment of Surgery, University of Virginia Health System, P.O. Box 800709, Charlottesville, VA, 22903, USA.ORCID http://orcid.org/0000-0003-3015-4126
J Hunter MehaffeyDepartment of Surgery, University of Virginia Health System, P.O. Box 800709, Charlottesville, VA, 22903, USA.
Robert B HawkinsDepartment of Surgery, University of Virginia Health System, P.O. Box 800709, Charlottesville, VA, 22903, USA.
Bruce D SchirmerDepartment of Surgery, University of Virginia Health System, P.O. Box 800709, Charlottesville, VA, 22903, USA.
Peter T HallowellDepartment of Surgery, University of Virginia Health System, P.O. Box 800709, Charlottesville, VA, 22903, USA.
Anneke T SchroenDepartment of Surgery, University of Virginia Health System, P.O. Box 800709, Charlottesville, VA, 22903, USA.
Shayna L ShowalterDepartment of Surgery, University of Virginia Health System, P.O. Box 800709, Charlottesville, VA, 22903, USA. snl2t@virginia.edu.
University of Virginia Health System · US

Funding

Cardiovascular Surgery Training ProgramT32HL007849 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KRON, IRVING L., LAUBACH, VICTOR E · 1998 to 2025
$7.0M
Postdoctoral Training Grant for MDs in Surgical Oncology ResearchT32CA163177 · NCI · UNIVERSITY OF VIRGINIA · PI Craig Lee Slingluff, Allan Tsung · 2011 to 2026
$4.6M
NIH HHS T32 CA163177NIH HHS T32 HL007849
6 · The paper itself

Abstract

introductionBariatric surgery treats morbid obesity resulting in long-lasting weight loss. Elevated body mass index (BMI) increases breast cancer risk. We hypothesized that patients undergoing bariatric surgery would have decreased overall and estrogen receptor (ER)-positive breast cancer incidences compared to a propensity-matched non-surgical cohort.

methodsThe bariatric population included all female patients who underwent weight loss surgery at a single institution from 1985 to 2015. Patients from all outpatient visits were propensity score matched 1:1 with bariatric patients using BMI, comorbidities, demographics, and insurance status. The primary outcome was breast cancer incidence. Univariate analyses compared the groups.

resultsA total of 4860 patients were included, with 2430 in both groups. Median follow-up time from date of surgery or morbid obesity diagnosis was 5.7 years. There were no differences in age or comorbidities aside from gastroesophageal reflux disease. Seventeen (0.7%) patients in the surgery group were subsequently diagnosed with breast cancer versus 32 (1.3%) in the non-surgery group (p = 0.03). The non-surgery group had more ER-positive tumors [4 (36.4%) vs. 22 (71.0%); p = 0.04].

conclusionFemale patients who underwent bariatric surgery were less frequently diagnosed with any breast cancer and ER-positive breast cancer versus a propensity-matched cohort suggesting a possible oncologic benefit to weight loss surgery.

Indexed as

AdultBariatric SurgeryBreast NeoplasmsFemaleHumansIncidenceMiddle AgedObesityReceptors, EstrogenRetrospective StudiesReceptors, EstrogenCancer riskMorbid obesityWeight loss surgery

Identifiers

PMID30536017
OpenAlexW2904381180

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.