ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2020
CRAX: A simple cardiovascular risk assessment tool to predict risk of acute myocardial infarction or death.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Prediction of 2-year major adverse cardiac events from myocardial perfusion scintigraphy and clinical risk factors.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Adding value to myocardial perfusion scintigraphy: A prediction tool to predict adverse cardiac outcomes and risk stratify.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Cardiovascular risk assessment models: Have we found the perfect solution yet?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Upper reference limits of transient ischemic dilation ratio for different protocols on new-generation cadmium zinc telluride cameras: A report from REFINE SPECT registry.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundDetermining the risk of cardiovascular events is essential to optimize patient management. METHODS AND
results5842 individuals underwent SPECT myocardial perfusion imaging (MPI) with 4.4 ± 1.2 years of follow-up. Models (the CRAX tool) were derived to predict the cumulative risk of death and acute myocardial infarction (AMI) at 1, 3, and 5 years using clinical and MPI variables. Predictors of AMI and death included age, number of hospitalizations in the 3 years preceding MPI, and left ventricular ejection fraction (LVEF). Additional predictors of death were the use of pharmacological stress, and global stress total perfusion deficit (sTPD), while transient ischemic dilation (TID), and ischemic total perfusion deficit (iTPD) change were predictive of AMI. CRAX predictions were significantly (P < .001) more accurate than clinical variables or MPI results alone, resulting in a significant net reclassification improvement (NRI, 7.5% for AMI, 14.5% death) compared to clinical variables alone. Accuracy for predicting major adverse cardiac events (MACE, comprising all-cause death, AMI, unstable angina, late revascularization) was comparable to that of AMI or death.
conclusionsCRAX is a risk assessment tool that predicts the risk of AMI, death, or MACE, and improves prediction compared to clinical variables or MPI results alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.