SynthesisDigestive diseases and sciences2019
Systematic Review: Efficacy and Safety of Accelerated Induction Regimes in Infliximab Rescue Therapy for Hospitalized Patients with Acute Severe Colitis.
Synthesis in Digestive diseases and sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Biologics in the management of pediatric inflammatory bowel disease: When and what to choose.World journal of clinical pediatrics · 2025Review
- Sequential rescue therapy with JAK inhibitors in corticosteroid and infliximab-refractory acute severe ulcerative colitis: a case series.Therapeutic advances in gastroenterology · 2025Article
- Future of Acute Severe Ulcerative Colitis-A Narrative Review.Journal of clinical medicine · 2024Review
- Recent Advances in the Management of Acute Severe Ulcerative Colitis.Journal of clinical medicine · 2024Review
- Predicting Outcome after Acute Severe Ulcerative Colitis: A Contemporary Review and Areas for Future Research.Journal of clinical medicine · 2024Review
- Unresolved challenges in acute severe ulcerative colitis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Article
- Modern practical management of acute severe colitis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Review
- Case Report: Medical Management of Acute Severe Ulcerative Colitis.Gastroenterology & hepatology · 2023Article
- How to manage: acute severe colitis.Frontline gastroenterology · 2022Article
- Treatment of acute severe ulcerative colitis using accelerated infliximab regimen based on infliximab trough level: A case report.World journal of clinical cases · 2021Article
- Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study.The lancet. Gastroenterology & hepatology · 2021Observational
- First United Arab Emirates consensus on diagnosis and management of inflammatory bowel diseases: A 2020 Delphi consensus.World journal of gastroenterology · 2020Article
- Infliximab in acute severe colitis: getting the right dose.Frontline gastroenterology · 2020Article
- Concise Commentary: Second Line Is Not Second Best-Continuing Validity of the Oxford Criteria in the Management of Acute Severe Ulcerative Colitis.Digestive diseases and sciences · 2020Article
- Practice pattern variability in the management of acute severe colitis: a UK provider survey.Frontline gastroenterology · 2020Article
- Colonic Dilatation Complicating Acute Severe Ulcerative Colitis Managed Successfully with Accelerated Infliximab Dosing.Case reports in gastroenterologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPharmacokinetic data suggest that standard induction dosing schedules may not be sufficient in patients with acute severe colitis (ASUC). Hence, intensified induction regimes are increasingly used in the rescue treatment of hospitalized patients with ASUC to avoid the need for colectomy although the evidence for this is uncertain.
aimTo conduct a systematic review of short- and long-term efficacy outcomes from accelerated infliximab induction studies.
methodsSystematic search of relevant databases (MEDLINE, EMBASE, Cochrane Database of Systematic Reviews) and relevant conference proceedings (Digestive Diseases Week, European Colitis and Crohn's Organisation Congress, United European Gastroenterology Week) was done.
resultsWe identified ten relevant studies with a total of 705 patients, of whom 308 received an intensified infliximab regime. Pooled analysis showed no difference in short-term or long-term colectomy rates in those receiving accelerated induction regimes when compared to standard induction. No significant differences in complication rates were identified.
conclusionsThe available uncontrolled studies so far do not suggest short-term or long-term benefit in using accelerated induction in hospitalized ASUC. The overall poor quality of available studies with confounding variables indicates the need for a randomized controlled trial with personalized risk stratification.
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