SynthesisHeart failure reviews2019
Improvement of hyponatremia is associated with lower mortality risk in patients with acute decompensated heart failure: a meta-analysis of cohort studies.
Synthesis in Heart failure reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Tolvaptan for water retention in heart failure: a systematic review.Systematic reviews · 2023Pooled it
- Impact of Vaptans on Clinical Outcomes in Cirrhosis Patients: A Meta-Analysis of Randomized Controlled Trials.Frontiers in pharmacology · 2019Pooled it
- Hyponatraemia in heart failure: a mechanistic approach to contemporary management.Heart failure reviews · 2026Review
- Hyponatremia and takotsubo syndrome: a review of pathogenetic and clinical implications.Heart failure reviews · 2024Review
- Hyponatremia Demystified: Integrating Physiology to Shape Clinical Practice.Advances in kidney disease and health · 2023Review
- Association between hyponatremia and adverse clinical outcomes of heart failure: current evidence based on a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Article
- A step-by-step guide for the diagnosis and management of hyponatraemia in patients with stroke.Therapeutic advances in endocrinology and metabolism · 2023Review
- Sodium-based osmotherapy for hyponatremia in acute decompensated heart failure.Heart failure reviews · 2022Review
- Etiology Analysis and Diagnosis and Treatment Strategy of Traumatic Brain Injury Complicated With Hyponatremia.Frontiers in surgery · 2022Article
- Sodium Intake and Heart Failure.International journal of molecular sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyponatremia at admission is predictive of poor prognosis in patients with acute decompensated heart failure (ADHF). We performed a meta-analysis of cohort studies to evaluate whether improvement of hyponatremia is associated with improved survival in patients with ADHF and hyponatremia. Relevant studies were identified through systematic search of PubMed and Embase. A random-effect model was used to pool the results. Predefined subgroup analyses were performed to explore the source of heterogeneity. Five thousand seven hundred fourteen patients with ADHF and hyponatremia from eight cohort studies were included. Results showed that improvement of hyponatremia during hospitalization was associated with lower risk of all-cause mortality (RR = 0.65, 95% CI 0.53 to 0.80, p < 0.001) as compared with those without improvement of hyponatremia. Results of subgroup analyses indicated that improvement of hyponatremia was associated with more remarkable changes of short-term (within 3 months after discharge) mortality (RR = 0.54) as compared with long-term mortality (RR = 0.74). Other factors such as study design, sample size, and heart failure subtypes did not affect the association. This was further confirmed by the meta-analysis of studies with multivariate analysis, which also suggested an association between improved hyponatremia and lower risk of all-cause mortality in ADHF patients (adjusted RR = 0.63, 95% CI 0.43 to 0.92, p = 0.02; I
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