Evidence map›Paper›PMID 30535831›Full record

ArticleNeurochemical research2020

Pathophysiology and Treatment of Canavan Disease.

David Pleasure, Fuzheng Guo, Olga Chechneva, Peter Bannerman, Jennifer McDonough, Travis Burns, Yan Wang, Vanessa Hull

Abstract read
In one paragraph

Article in Neurochemical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trial
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  15. Function ofFrontiers in microbiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

David PleasureInstitute for Pediatric Regenerative Research, Shriners Hospitals for Children Northern California and UC Davis School of Medicine, 2425 Stockton Blvd, 95817, Sacramento, CA, USA. depleasure@ucdavis.edu.ORCID 0000-0002-9122-1268
Fuzheng GuoInstitute for Pediatric Regenerative Research, Shriners Hospitals for Children Northern California and UC Davis School of Medicine, 2425 Stockton Blvd, 95817, Sacramento, CA, USA.
Olga ChechnevaInstitute for Pediatric Regenerative Research, Shriners Hospitals for Children Northern California and UC Davis School of Medicine, 2425 Stockton Blvd, 95817, Sacramento, CA, USA.
Peter BannermanInstitute for Pediatric Regenerative Research, Shriners Hospitals for Children Northern California and UC Davis School of Medicine, 2425 Stockton Blvd, 95817, Sacramento, CA, USA.
Jennifer McDonoughDepartment of Biological Sciences, School of Biomedical Sciences, Kent State University, Kent, OH, 44242, USA.
Travis BurnsInstitute for Pediatric Regenerative Research, Shriners Hospitals for Children Northern California and UC Davis School of Medicine, 2425 Stockton Blvd, 95817, Sacramento, CA, USA.
Yan WangInstitute for Pediatric Regenerative Research, Shriners Hospitals for Children Northern California and UC Davis School of Medicine, 2425 Stockton Blvd, 95817, Sacramento, CA, USA.
Vanessa HullInstitute for Pediatric Regenerative Research, Shriners Hospitals for Children Northern California and UC Davis School of Medicine, 2425 Stockton Blvd, 95817, Sacramento, CA, USA.

Funding

The Wnt-independent role of TCF7l2 in CNS myelin formation and repairR01NS094559 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GUO, FUZHENG · 2016 to 2020
$1.4M
CANAVAN DISEASE: SUPPRESSING THE PHENOTYPE BY INHIBITING NAA SYNTHESISR21NS096004 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PLEASURE, DAVID E. · 2015 to 2016
$431k
Dana Foundation n/aNINDS NIH HHS 1R21NS096004NINDS NIH HHS R01 NS094559NINDS NIH HHS R21 NS096004Shriners Hospitals for Children 439043
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AcetyltransferasesAmidohydrolasesAnimalsAspartic AcidAstrocytesCanavan DiseaseCerebellumGene Knockout TechniquesHumansMiceOligodendrogliaRNA, Small InterferingSymportersTransduction, GeneticAcetyltransferasesAmidohydrolasesAspartic AcidaspartoacylaseN-acetylaspartateRNA, Small InterferingShati protein, mouseSlc13a3 protein, mouseSymportersAspartoacylase (encoded by ASPA)Canavan diseaseGene therapyN-acetyl-L-aspartate (NAA)N-acetyltransferase 8-like (encoded by Nat8l)NaDC3 (encoded by Slc13a3)Vacuolar (“spongiform”) leukodystrophy

Identifiers

PMID30535831
PMCPMC11131954

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.