ArticleGenetica2019
Excess of retrogene traffic in pig X chromosome.
Article in Genetica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 5 citations in OpenAlex.
- Novel insights into retrogene evolution and cold adaptation in the alpine plant Crucihimalaya himalaica (Brassicaceae).BMC biology · 2026Article
- Unraveling the complex evolutionary history of lepidopteran chromosomes through ancestral chromosome reconstruction and novel chromosome nomenclature.BMC biology · 2023Article
- Positive selection-driven fixation of a hominin-specific amino acid mutation related to dephosphorylation in IRF9.BMC ecology and evolution · 2022Article
- The de novo assembly of a European wild boar genome revealed unique patterns of chromosomal structural variations and segmental duplications.Animal genetics · 2022Article
- TheFrontiers in genetics · 2022Article
- Editorial: Application in evolutionary novelties and diversities: Medicine, agriculture, and conservation.Frontiers in genetics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Despite the insights into retrogene evolution in multiple species provided by trans-traffic retrogenes (trans-retrogenes), cis-traffic retrogenes (cis-retrogenes) are hitherto understudied and thus limit our understanding of genetic novelty. Here we used the pig genome as a model to compare cis- and trans-retrogenes. We found that cis- and trans-retrogenes have similar patterns in terms of excessive X-chromosome representation, testis expression preference, and metabolic functional enrichment. Despite these similarities, lower levels of selective pressure were found in cis- than in trans-retrogenes. The evolutionary dating evidence revealed that more cis-retrogenes have originated after pig-cattle divergence than trans-retrogenes, suggesting a more recent origination of cis-retrogenes. The gene family clustering confirmed that excesses of X-derived cis-retrogenes may be driven by their rapid expansion in the recent times. Thus, the different selective constraints between cis- and trans-retrogenes may be due to different evolutionary time-scales rather than any differential functional importance. Thus, this study highlights the ongoing functional contributions from cis- and trans-traffic retrogenes during the reshaping of pig genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.