ArticleHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2019
Hypertension is Common in Patients with Newly Diagnosed Acromegaly and is Independently Associated with Renal Resistive Index.
Article in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 6 citations in OpenAlex.
- From Subtle Signs to Severe Sequelae-A Century of Symptomatology and Comorbidities in the Diagnosis of GH-Secreting Pituitary Neuroendocrine Tumors: A Systematic Review.Diagnostics (Basel, Switzerland) · 2025Review
- Carotid femoral pulse wave velocity and serum galectin-3 level significantly increases in patients with acromegaly.Medicine · 2025Observational
- The relationship between morning blood pressure surge and serum IGF-1 level in acromegaly patients with hypertension.Irish journal of medical science · 2024Article
- Serum Elabela level is significantly increased in patients with acromegaly.Irish journal of medical science · 2023Article
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2 authors at 1 institution in 1 country.
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Abstract
introductionThere are conflicting results regarding the frequency of hypertension (HT) and values of related parameters in patients with acromegaly.
aimWe aimed to determine the frequency of HT and values of its associated parameters in patients with acromegaly.
methods57 patients with newly diagnosed acromegaly were included in this study. Renal ultrasonography (US) was performed in addition to routine evaluation of acromegaly. Renal resistive index (RRI), renal pulsatility index (RPI), and accelerated time were measured using Doppler US.
resultsHypertension was detected in 16 patients (28.1%) with newly diagnosed acromegaly. Serum triglyceride, TSH, growth hormone, and insulin growth factor 1 levels were higher and HDL levels were lower in acromegaly patients with HT. RRI and RPI values were found to be higher in acromegaly patients with HT. In logistic regression analysis, only the RRI value was found to be independently related to the presence of HT. Based on this analysis, it was determined that the frequency of HT increases 2.99 times for each increase in RRI of 0.05 units. When ROC analysis was performed, it was found that the area under the ROC curve was 0.781. In the same analysis, when the cutoff value for RRI was taken to be 0.70, the development of HT in acromegaly patients was determined with 75% sensitivity and 78% specificity.
conclusionsIn patients with newly diagnosed acromegaly, HT frequency was significantly increased and it was independently associated with the RRI value. Therefore, these patients should be closely monitored for HT-the most frequent and important cardiovascular risk factor-and treated before they develop target organ damage.
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