Evidence map›Paper›PMID 30535790›Full record

ArticleJournal of molecular neuroscience : MN2019

An Intraperitoneal Treatment with Calcitonin Gene-Related Peptide (CGRP) Regulates Appetite, Energy Intake/Expenditure, and Metabolism.

Daniel Sanford, Leon Luong, Arielle Gabalski, Suwan Oh, John P Vu, Joseph R Pisegna, Patrizia Germano

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Daniel SanfordCURE/Digestive Diseases Research Center, Department of Medicine at the David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Leon LuongCURE/Digestive Diseases Research Center, Department of Medicine at the David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Arielle GabalskiCURE/Digestive Diseases Research Center, Department of Medicine at the David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Suwan OhCURE/Digestive Diseases Research Center, Department of Medicine at the David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
John P VuCURE/Digestive Diseases Research Center, Department of Medicine at the David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Joseph R PisegnaCURE/Digestive Diseases Research Center, Department of Medicine at the David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Patrizia GermanoCURE/Digestive Diseases Research Center, Department of Medicine at the David Geffen School of Medicine, University of California, Los Angeles, CA, USA. pgermano@ucla.edu.ORCID http://orcid.org/0000-0003-0996-3295
University of California, Los Angeles · US

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
Gastrointestinal Hormonal Regulation of ObesityI01RX000194 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI PISEGNA, JOSEPH R, TACHE, YVETTE FRANCE · 2012 to 2015
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Regulation of Appetite and Obesity by PACAPI01RX000873 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI GERMANO, PATRICIA MARIA · 2015 to 2015
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Acquisition of a Promethion Continuous Metabolic SystemIS1BX003075 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI GERMANO, PATRICIA MARIA · 2015 to 2015
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ShEEP Request for Keyence All-in-One MicroscopeIS1BX003553 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI GERMANO, PATRICIA MARIA · 2016 to 2016
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BLRD VA IS1 BX003075BLRD VA IS1 BX003553National Institute of Diabetes and Digestive and Kidney Diseases P30 NIH DK41301National Institute of Diabetes and Digestive and Kidney Diseases U01 CSCPDPC -CCs -RFA-DK-14-027NIDDK NIH HHS P30 DK041301RRD VA I01 RX000194RRD VA I01 RX000873U.S. Department of Veterans Affairs I01RX000873U.S. Department of Veterans Affairs IS1BX003075U.S. Department of Veterans Affairs IS1BX003553
6 · The paper itself

Abstract

Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide expressed both centrally and peripherally. CGRP has been shown to be involved in arteriolar dilation, cardiovascular regulation, pain transmission, migraine, and gastrointestinal physiology. Our current research is aimed at analyzing CGRP's impact on appetite/satiety, body metabolism, and energy homeostasis. Our study investigated the effects of a single-dose intraperitoneal (IP) treatment with CGRP on food and water consumption, energy expenditure, physical activity, respirometry, and a panel of plasma metabolic hormones in C57Bl/6 wild-type (WT) mice. After a CGRP IP injection at a dose of 2 nmol (10 μM CGRP in 200 μl of saline), a significant reduction in food intake and metabolic parameters as RQ, VCO

Indexed as

AppetiteEnergy MetabolismAnimalsAppetite DepressantsCalcitonin Gene-Related PeptideFemaleGlucagonInjections, IntraperitonealLeptinMaleMiceMice, Inbred C57BLAppetite DepressantsCalcitonin Gene-Related PeptideGlucagonLeptinAppetiteCalcitonin gene-related peptideMetabolic hormonesMetabolism

Identifiers

PMID30535790
PMCPMC6736536
OpenAlexW2904705509

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.