Evidence map›Paper›PMID 30535736›Full record

ArticleEnvironmental science and pollution research international2019

Curcumin and quercetin synergistically attenuate subacute diazinon-induced inflammation and oxidative neurohepatic damage, and acetylcholinesterase inhibition in albino rats.

Mohamed M Abdel-Diam, Dalia H Samak, Yasser S El-Sayed, Lotfi Aleya, Saud Alarifi, Saad Alkahtani

Abstract read
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In one paragraph

Article in Environmental science and pollution research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 62 citations in OpenAlex.

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  15. The protective effects of hesperidin and curcumin on 5-fluorouracil-induced nephrotoxicity in mice.Environmental science and pollution research international · 2021
    Article
  16. Review
  17. Article
  18. Molecular effects of curcumin on the experimental autoimmune encephalomyelitis.Veterinary research forum : an international quarterly journal · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Mohamed M Abdel-DiamPharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41522, Egypt. abdeldaim.m@vet.suez.edu.eg.ORCID http://orcid.org/0000-0002-4341-2713
Dalia H SamakDepartment of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Damanhour University, Damanhour, 22511, Egypt.
Yasser S El-SayedDepartment of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Damanhour University, Damanhour, 22511, Egypt.
Lotfi AleyaChrono-Environnement Laboratory, UMR CNRS 6249, Bourgogne Franche-Comté University, 25030, Besançon Cedex, France.
Saud AlarifiDepartment of Zoology, Science College, King Saud University, Riyadh, Saudi Arabia.
Saad AlkahtaniDepartment of Zoology, Science College, King Saud University, Riyadh, Saudi Arabia.
Damanhour University · EGKing Saud University · SACentre National de la Recherche Scientifique · FRSuez Canal University · EG

Funding

The Deanship of Scientific Research at King Saud University RGP-018
6 · The paper itself

Abstract

The ubiquitous use of diazinon (DZN, an organophosphorus insecticide) has increased the probability of occupational, public, and the ecosystem exposure; these exposures are linked to negative health outcomes. The flavonoids curcumin (CUR) and quercetin (QUE) exert significant anti-inflammatory and antioxidant activities against toxicants, including insecticides. However, it is unclear whether their combination enhances these activities. Therefore, 40 albino rat were divided randomly into the CTR, DZN, CUR + DZN, QUE + DZN, and CUR + QUE + DZN groups, which are treated daily via gavage for 28 days. DZN induced neurohepatic inflammation and oxidative damage, which was confirmed by significant (P < 0.05) induction of aspartate and alanine aminotransferases, alkaline phosphatase, lactate dehydrogenase, γ-glutamyl transferase, and tumor necrosis factor-α and inhibition of acetylcholinesterase activity. Furthermore, the liver and brain of DZN-exposed rats exhibited a notable elevation in MDA level paralleled with reduction in antioxidant molecules, i.e., glutathione, superoxide dismutase, glutathione peroxidase, and catalase. The pretreatment of DZN-intoxicated rats with CUR or QUE substantially mitigated neurohepatic dysfunction and inflammation and improved liver and brain antioxidant status with reducing oxidative stress levels. Furthermore, pretreatment with CUR + QUE synergistically restored the neurohepatic dysfunction and oxidative levels to approximately normal levels. The overall results suggested that CUR or QUE inhibits DZN-mediated neurohepatic toxicity via their favorable anti-inflammatory, antioxidant, and free radical-scavenging activities. Moreover, both QUE and CUR may be mutual adjuvant agents against oxidative stress neurohepatic damages.

Indexed as

AcetylcholinesteraseAnimalsAntioxidantsBrainCholinesterase InhibitorsCurcuminDiazinonDrug SynergismEnzymesGlutathioneInflammationInsecticidesLiverMaleOxidative StressQuercetinAcetylcholinesteraseAntioxidantsCholinesterase InhibitorsCurcuminDiazinonEnzymesGlutathioneInsecticidesQuercetinAcetylcholinesteraseAnti-inflammatoryAntioxidantCurcuminDiazinonOxidative stressQuercetin

Identifiers

PMID30535736
OpenAlexW2905581577

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.