Evidence map›Paper›PMID 30535674›Full record

ArticleProbiotics and antimicrobial proteins2019

Putative Microbial Population Shifts Attributable to Nasal Administration of Streptococcus salivarius 24SMBc and Streptococcus oralis 89a.

Roberta De Grandi, Lorenzo Drago, Alessandro Bidossi, Marta Bottagisio, Matteo Gelardi, Elena De Vecchi

Abstract read
In one paragraph

Article in Probiotics and antimicrobial proteins, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. The Microbiome of the Nose-Friend or Foe?Allergy & rhinology (Providence, R.I.)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Roberta De GrandiLaboratory of Clinical Chemistry and Microbiology, IRCCS Orthopedic Institute Galeazzi, Via Galeazzi 4, 20164, Milan, Italy. roberta.degrandi@grupposandonato.it.ORCID http://orcid.org/0000-0001-5588-1659
Lorenzo DragoLaboratory of Clinical Microbiology, Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
Alessandro BidossiLaboratory of Clinical Chemistry and Microbiology, IRCCS Orthopedic Institute Galeazzi, Via Galeazzi 4, 20164, Milan, Italy.
Marta BottagisioLaboratory of Clinical Chemistry and Microbiology, IRCCS Orthopedic Institute Galeazzi, Via Galeazzi 4, 20164, Milan, Italy.
Matteo GelardiOtolaryngology Unit, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari Aldo Moro, Bari, Italy.
Elena De VecchiLaboratory of Clinical Chemistry and Microbiology, IRCCS Orthopedic Institute Galeazzi, Via Galeazzi 4, 20164, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Changes in bacterial composition of nasal microbiota may alter the host's susceptibility to several infectious and allergic diseases such as chronic rhinosinusitis and allergic rhinitis. The aim of this study was to evaluate the effects of 1-week administration of a probiotic product, composed by a combination of Streptococcus salivarius 24SMBc and Streptococcus oralis 89a, on the nostril microbiota. Differences in the nasal microbiota composition were investigated by using a next-generation sequencing approach. A strong and significant decrease in Staphylococcus aureus abundance was detected immediately after the bacterial administration. Moreover, comparing the microbial networks of nostril microbiota before and 1 month after the end of treatment, we detected an increase in the total number of both bacterial nodes and microbial correlations, with particular regard to the beneficial ones. Furthermore, a less abundance of microbial genera commonly associated to potential harmful bacteria has been observed. These results suggest a potential ability of S. salivarius 24SMBc and S. oralis 89a to regulate and reorganize the nasal microbiota composition, possibly favoring those microorganisms that may be able to limit the overgrowth of potential pathogens.

Indexed as

MicrobiotaAdministration, IntranasalAdultBacteriaFemaleHumansMaleNoseProbioticsStreptococcus oralisStreptococcus salivarius16S RNA gene sequencingMicrobial networksNasal bacteria

Identifiers

PMID30535674
PMCPMC6854047

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.