Evidence map›Paper›PMID 30535636›Full record

ArticleImmunogenetics2019

Evidence of functional Cd94 polymorphism in a free-living house mouse population.

Linn E Knutsen, Erik Dissen, Per C Saether, Elisabeth Gyllensten Bjørnsen, Jaroslav Piálek, Anne K Storset, Preben Boysen

Abstract read
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In one paragraph

Article in Immunogenetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Linn E KnutsenFaculty of Veterinary Medicine, Department of Food Safety and Infection Biology (MatInf), Norwegian University of Life Sciences (NMBU), Oslo, Norway.
Erik DissenDivision of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Per C SaetherDivision of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Elisabeth Gyllensten BjørnsenDivision of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Jaroslav PiálekResearch Facility Studenec, Institute of Vertebrate Biology of the Czech Academy of Sciences, Brno, Czech Republic.
Anne K StorsetFaculty of Veterinary Medicine, Department of Food Safety and Infection Biology (MatInf), Norwegian University of Life Sciences (NMBU), Oslo, Norway.
Preben BoysenFaculty of Veterinary Medicine, Department of Food Safety and Infection Biology (MatInf), Norwegian University of Life Sciences (NMBU), Oslo, Norway. preben.boysen@nmbu.no.ORCID 0000-0002-0084-1251
Norwegian University of Life Sciences · NOUniversity of Oslo · NOCzech Academy of Sciences, Institute of Vertebrate Biology · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The CD94 receptor, expressed on natural killer (NK) and CD8+ T cells, is known as a relatively non-polymorphic receptor with orthologues in humans, other primates, cattle, and rodents. In the house mouse (Mus musculus), a single allele is highly conserved among laboratory strains, and reports of allelic variation in lab- or wild-living mice are lacking, except for deficiency in one lab strain (DBA/2J). The non-classical MHC-I molecule Qa-1b is the ligand for mouse CD94/NKG2A, presenting alternative non-americ fragment of leader peptides (Qa-1 determinant modifier (Qdm)) from classical MHC-I molecules. Here, we report a novel allele identified in free-living house mice captured in Norway, living among individuals carrying the canonical Cd94 allele. The novel Cd94

Indexed as

Polymorphism, GeneticAllelesAmino Acid SequenceAnimalsCD8-Positive T-LymphocytesCHO CellsCricetinaeCricetulusHEK293 CellsHistocompatibility Antigens Class IHumansKiller Cells, NaturalMice, Inbred C57BLMice, Inbred DBANK Cell Lectin-Like Receptor Subfamily CNK Cell Lectin-Like Receptor Subfamily DHistocompatibility Antigens Class INK Cell Lectin-Like Receptor Subfamily CNK Cell Lectin-Like Receptor Subfamily DPeptidesQdm protein, mouseQ surface antigensComparative immunology/evolutionGenomicsInhibitory/activating receptorsMHCNK cell

Identifiers

PMID30535636
OpenAlexW2905200243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.