ArticleAging clinical and experimental research2019
Factors influencing attrition in 35 Alzheimer's Disease Centers across the USA: a longitudinal examination of the National Alzheimer's Coordinating Center's Uniform Data Set.
Article in Aging clinical and experimental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- The Prognostic Utility of Anticholinergic Burden Scales: An Integrative Review and Gap Analysis.Drugs & aging · 2023Pooled it
- Prognostic factors for functional decline in community-dwelling older adults with dementia: a systematic review and meta-analysis.European geriatric medicine · 2026Review
- Evaluating the 8-Year Association Between Cognition and Beta Amyloid in the Dallas Lifespan Brain Study Cohort.Brain and behavior · 2026Article
- Major Adverse Cognitive Events (MACE-Cog): A New "MACE" Framework for Cognitive Outcomes in Cardiovascular Diseases and Stroke.Circulation · 2026Review
- Understanding attrition: Feasibility and acceptability of a behavioral intervention for dementia care partners.medRxiv : the preprint server for health sciences · 2026Article
- Pathways to participation - a scoping review outlining barriers and enablers to participation in dementia research.The journal of prevention of Alzheimer's disease · 2026Article
- SOCAV, a nurse-led program promoting self-direction in nursing homes: a longitudinal mixed-methods pilot study.BMC geriatrics · 2026Article
- Experiences of participant burden in an Alzheimer's disease research center longitudinal cohort.Journal of Alzheimer's disease : JAD · 2026Article
- Solving the 'Goldilocks problem' in dementia clinical trials with multimodal AI.The journal of prevention of Alzheimer's disease · 2025Article
- MRI-DTI Biomarkers Along the Continuum of Behavioral Variant Frontotemporal Dementia.European journal of neurology · 2025Article
- Factors Affecting Nonresponse Among Female Participants in the Korea Nurses' Health Study: Longitudinal Cohort Survey Study.JMIR public health and surveillance · 2025Article
- At-home wearables and machine learning capture motor impairment and progression in adult ataxias.Brain : a journal of neurology · 2025Article
- Who stays? Understanding the attrition in a longitudinal aging study of older Chinese immigrants in the United States.Innovation in aging · 2025Article
- Feasibility of telephone and computerized cognitive testing as a secondary outcome in an acute stroke clinical trial: A mixed methods sub-study of the AcT Trial.European stroke journal · 2025Article
- Predictors of Retention in the 1Florida Alzheimer's Disease Research Center (ADRC) Over Two Waves.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025Article
- Loss to Follow-Up in Intermediate Age-Related Macular Degeneration Patients Enrolled in the University of Colorado AMD Registry.Ophthalmic epidemiology · 2025Article
- Longitudinal changes in brain connectivity correlate with neuropsychological testing in brain tumor resection patients.Frontiers in neuroscience · 2025Article
- Estimating attrition in mild-to-moderate Alzheimer's disease and mild cognitive impairment clinical trials.Alzheimer's research & therapy · 2023Article
- Article
- Robust estimation of dementia prevalence from two-phase surveys with non-responders via propensity score stratification.BMC medical research methodology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveA lack of understanding of the causes of attrition in longitudinal studies of older adults may lead to higher attrition rates and bias longitudinal study results. In longitudinal epidemiological studies of Alzheimer's disease and related dementias, high rates of attrition may cause a systematic underestimation of dementia prevalence and skew the characterization of the disease. This can compromise the generalizability of the study results and any inferences based on the surviving sample may grossly misrepresent the importance of the risk factors for dementia. The National Institute on Aging outlined a National Strategy for Recruitment and Participation in Alzheimer's Disease Clinical Research to address this problem, providing evidence of the magnitude of this problem.
methodTo explore predictors of attrition, this study examined the National Alzheimer's Coordinating Center (NACC) Uniform Data Set, a repository of observations of older adults spanning 11 years, using survival analysis. Four samples were examined: the full sample (n = 30,433), the alive subsample excluding those who died (n = 24,231), the MRI sample [participants with complete MRI data (n = 1104)], and the alive MRI subsample [participants with MRI data excluding those who died (n = 947)].
resultsWorsening cognitive impairment, neuropsychiatric symptoms, and difficulty with functional activities predicted attrition, as did lower hippocampal volume in the MRI subsample. Questionable co-participant reliability and an informant other than a spouse also increased risk of attrition. DISCUSSION: Special considerations exist in recruiting and retaining older adults in longitudinal studies, and results of baseline psychological, functional, and cognitive functioning should be used to identify targeted retention strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.