ArticleAnnals of intensive care2018
Driving pressure and long-term outcomes in moderate/severe acute respiratory distress syndrome.
Article in Annals of intensive care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Respiratory Mechanics and Gas Exchange in Patients With COVID-19 and Hypoxemic Acute Respiratory Failure: Multicentral Observational Study
Follow-up and Rehabilitation of Survivors of Severe Covid-19 Infection
Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Comparison of limited driving pressure ventilation and low tidal volume strategies in adults with acute respiratory failure on mechanical ventilation: a randomized controlled trial.Therapeutic advances in respiratory diseaseTrial
- Beyond One-Size-Fits-All: Precision Mechanical Ventilation in ARDS.Journal of clinical medicine · 2026Review
- Postoperative outcomes following anatomical lung resections in relation to intraoperative ventilation practices: a registry-based multicenter study.Frontiers in surgery · 2026Article
- Neuroleptics used in critical COVID associated with moderate-severe dyspnea after hospital discharge.Scientific reports · 2025Article
- Article
- Article
- Driving Pressure, Elastance, and Outcomes in a Real-World Setting: A Bi-Center Analysis of Electronic Health Record Data.Critical care explorations · 2023Article
- Lung morphology impacts the association between ventilatory variables and mortality in patients with acute respiratory distress syndrome.Critical care (London, England) · 2023Article
- Long-term respiratory follow-up of ICU hospitalized COVID-19 patients: Prospective cohort study.PloS one · 2023Article
- Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial.Intensive care medicine · 2022Article
- ARDS Clinical Practice Guideline 2021.Journal of intensive care · 2022Article
- Article
- Intraoperative Protective Mechanical Ventilation in Dogs: A Randomized Clinical Trial.Frontiers in veterinary science · 2022Article
- Functional pathophysiology of SARS-CoV-2-induced acute lung injury and clinical implications.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Review
- Relationship between Driving Pressure and Mortality in Ventilated Patients with Heart Failure: A Cohort Study.Canadian respiratory journal · 2021Article
- Lung Mechanics of Mechanically Ventilated Patients With COVID-19: Analytics With High-Granularity Ventilator Waveform Data.Frontiers in medicine · 2020Article
- PEEP guided by electrical impedance tomography during one-lung ventilation in elderly patients undergoing thoracoscopic surgery.Annals of translational medicine · 2019Article
- Functional independence and spirometry in adult post-intensive care unit patients.Revista Brasileira de terapia intensivaArticle
- COVID-19: long-term respiratory consequences.Sao Paulo medical journal = Revista paulista de medicinaArticle
Corrections and comments
- Commented on by
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute respiratory distress syndrome (ARDS) patients may present impaired in lung function and structure after hospital discharge that may be related to mechanical ventilation strategy. The aim of this study was to evaluate the association between functional and structural lung impairment, N-terminal-peptide type III procollagen (NT-PCP-III) and driving pressure during protective mechanical ventilation. It was a secondary analysis of data from randomized controlled trial that included patients with moderate/severe ARDS with at least one follow-up visit performed. We obtained serial measurements of plasma NT-PCP-III levels. Whole-lung computed tomography analysis and pulmonary function test were performed at 1 and 6 months of follow-up. A health-related quality of life survey after 6 months was also performed.
resultsThirty-three patients were enrolled, and 21 patients survived after 6 months. In extubation day an association between driving pressure and NT-PCP-III was observed. At 1 and 6 months forced vital capacity (FVC) was negatively correlated to driving pressure (p < 0.01). At 6 months driving pressure was associated with lower FVC independently on tidal volume, plateau pressure and baseline static respiratory compliance after adjustments (r
conclusionEven in patients ventilated with protective tidal volume, higher driving pressure is associated with worse long-term pulmonary function and structure.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.