ArticleInternational journal of molecular medicine2019
Expression of microRNA‑27a in a rat model of osteonecrosis of the femoral head and its association with TGF‑β/Smad7 signalling in osteoblasts.
Article in International journal of molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- [Mechanisms of RNA-binding protein phase separation in steroid-associated necrosis of the femoral head].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Review
- Advances in the mechanism for steroid-induced osteonecrosis of the femoral head.Bone research · 2026Review
- Functional hydrogel empowering 3D printing titanium alloys.Materials today. Bio · 2025Review
- MicroRNA‑4327 regulates TGF‑β1 stimulation of matrix metalloproteinase‑13 expression via CREB‑binding protein‑mediated Runx2 acetylation in human osteoblasts.Experimental and therapeutic medicine · 2025Article
- YTHDF2-Mediated m6A methylation inhibition by miR27a as a protective mechanism against hormonal osteonecrosis in BMSCs.BMC musculoskeletal disorders · 2024Article
- Circ_ST6GAL1-mediated competing endogenous RNA network regulates TGF-β1-stimulated matrix Metalloproteinase-13 expression via Runx2 acetylation in osteoblasts.Non-coding RNA research · 2024Article
- Insight into Steroid-Induced ONFH: The Molecular Mechanism and Function of Epigenetic Modification in Mesenchymal Stem Cells.Biomolecules · 2023Review
- Fibroblast growth factor 23 regulates hypoxia‑induced osteoblast apoptosis through the autophagy‑signaling pathway.Molecular medicine reports · 2023Article
- Mesenchymal Stem Cell-Derived Extracellular Vesicles Inhibit Osteoporosis via MicroRNA-27a-Induced Inhibition of DKK2-Mediated Wnt/β-Catenin Pathway.Inflammation · 2022Article
- Mg-HA-C/C Composites Promote Osteogenic Differentiation and Repair Bone Defects Through Inhibiting miR-16.Frontiers in bioengineering and biotechnology · 2022Article
- Emerging roles of growth factors in osteonecrosis of the femoral head.Frontiers in genetics · 2022Review
- CircPVT1 up-regulation attenuates steroid-induced osteonecrosis of the femoral head through regulating miR-21-5p-mediated Smad7/TGFβ signalling pathway.Journal of cellular and molecular medicine · 2021Article
- Down-regulated microRNA-141 facilitates osteoblast activity and inhibits osteoclast activity to ameliorate osteonecrosis of the femoral head via up-regulating TGF-β2.Cell cycle (Georgetown, Tex.) · 2020Article
- Noncoding RNAs in Steroid-Induced Osteonecrosis of the Femoral Head.BioMed research international · 2019Review
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6 authors.
Funding
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Abstract
The present study assessed whether microRNA (miR)‑27a is an influential factor in steroid‑induced osteonecrosis of the femoral head (ONFH) and investigated the underlying mechanism of action. The results indicated that serum miR‑27a was decreased in a rat model of ONFH compared with that in control rats. It was also observed that increased miR‑27a expression promoted osteogenic differentiation and cell proliferation, inhibited caspase‑3/9 and B‑cell lymphoma‑2‑associated X protein expression and induced alkaline phosphatase (ALP) activity and bone morphogenetic protein (BMP)‑2, runt‑related transcription factor (Runx)2 and osteonectin mRNA expression in osteoblastic MC3T3‑E1 cells. miR‑27a mimics also induced transforming growth factor (TGF)‑β and Smad7 protein expression in MC3T3‑E1 cells. Furthermore, transfection with TGF‑β expression plasmid was able to enhance the effects of miR‑27a mimics on osteoblastic differentiation, cell proliferation, ALP activity, BMP‑2, Runx2 and osteonectin mRNA expression, and Smad7 protein expression in the MC3T3‑E1 cells. Transfection with a TGF‑β or Smad7 expression plasmid also enhanced the effects of miR‑27a mimics on osteoblastic differentiation, cell proliferation, ALP activity and osteonectin mRNA expression in the MC3T3‑E1 cells. Taken together, the results of the present study suggested that the induction of TGF‑β/Smad7 signaling in osteoblasts may be a potential mechanism by which miR‑27a regulates steroid‑induced ONFH.
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