ArticleJournal of insect science (Online)2018
Evolutionary Analysis of the Highly Conserved Insect Odorant Coreceptor (Orco) Revealed a Positive Selection Mode, Implying Functional Flexibility.
Article in Journal of insect science (Online), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Evolutionary Patterns of the Genes Involved in the Integrity and Segregation of Chromosomes in Sawflies (Hymenoptera: Symphyta).Ecology and evolution · 2026Article
- Early hexapod genomes reveal the deep origin of insect gustatory and odorant receptors.Nature communications · 2026Article
- Genome-Wide Identification and Characterization of Chemosensory Gene Families in the MayflyGenes · 2026Article
- Reducing Close Encounters with Insect Pests and Vectors: The Past, Present and Future of Insect Repellents.Insects · 2026Review
- Odorant Binding Proteins inInsects · 2025Review
- Comparative Expression Analysis of Olfactory Receptor Genes Among Individuals With Soldier and Worker Caste Differentiation Fates in Termites.Ecology and evolution · 2025Article
- Ecological Adaptation in the Chemosensory Gene Repertoire of the Safflower Aphid,International journal of molecular sciences · 2025Article
- Locusts adopt IPScience advances · 2025Article
- Antennal RNAseq reveals odorant receptors with sex-biased expression in the common eastern firefly, Photinus pyralis.BMC genomics · 2025Article
- Phenethyl Acetate as an Agonist of Insect Odorant Receptor Co-Receptor (Orco): Molecular Mechanisms and Functional Insights.International journal of molecular sciences · 2025Article
- Nuclear genome assembly of Leucinodes orbonalis (Lepidoptera: Crambidae) collected from the Philippines.Journal of insect science (Online) · 2025Article
- Article
- Identification of 2,4-Di-International journal of molecular sciences · 2023Article
- Mutagenesis of Odorant Receptor CoreceptorInternational journal of molecular sciences · 2023Article
- Article
- Chemoreceptor co-expression ineLife · 2022Article
- Molecular characterization and expression variation of the odorant receptor co-receptor in the Formosan subterranean termite.PloS one · 2022Article
- Evolution of the Insect PPK Gene Family.Genome biology and evolution · 2021Article
- Altered functional properties of the codling moth Orco mutagenized in the intracellular loop-3.Scientific reports · 2021Article
- Whole-exome sequencing identifies novel mutations in ABC transporter genes associated with intrahepatic cholestasis of pregnancy disease: a case-control study.BMC pregnancy and childbirth · 2021Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Odorant coreceptor (Orco) represents one of the essential genes in the insect olfactory system, which facilitates signal transduction and heterodimerization with different odorant receptors (Ors) in the insect antennal dendritic membrane. Evolutionary analysis by detecting positive selection is important to examine the functional flexibility of Orco that potentially supports insect survival. The maximum likelihood codon substitution model was applied using CODEML program as implemented in PAML ver 4.9e package across 59 Orco codon sequences available from GenBank. These sequences represented five major insect orders and two reproductive systems (holometabola and nonholometabola). In the site model that identified common ω values for Orco, it was clearly shown that Orco was under strong purifying selection, indicated by the ω value that was far from 1 (ω: 0.03). However, in to the branch model, positive selection was detected to be acting on Dipteran lineages, whereas in the branch-site model, several sites were under significant positive selection occurring in the following four clades: Coleoptera, Diptera, Lepidoptera, and Psocodea. The typical evolutionary mode acting on Orco was consistent with the entropy value [H(x)], confirming that 48.9% of the Orco site was under conservation (H(x) < 0.5), whereas 26.9% of the Orco sites was under high variation (H(x) > 1). These findings confirmed that Orco genes are generally highly conserved and can possibly be used for the manipulation of insect pest control programs. However, positive selection that acts on certain lineages suggested future adaptive evolutionary ability of Orco to anticipate flexible functions for successful olfactory processes.
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