ArticleCerebral cortex (New York, N.Y. : 1991)2019
Age-Related Differences in Brain Morphology and the Modifiers in Middle-Aged and Older Adults.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Alcohol and brain structure across the lifespan: A systematic review of large-scale neuroimaging studies.Addiction biology · 2024Pooled it
- An electric field modeling study with meta-analysis to understand the antidepressant effects of transcranial direct current stimulation (tDCS).Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Pooled it
- Growth of White Matter Signal Aberrations and Cortical Changes in Men and Women: A 9-Year Multiple-Time-Point Longitudinal MRI Study in Older Adults.Human brain mapping · 2026Article
- Structural brain indicators of cognitive performance in middle and late adulthood: The Human Connectome Project in Aging/Aging Adult Brain Connectome cohort.Neurobiology of aging · 2026Article
- Cognitive Reserve and Psychological Well-Being in Aging Population of Community-Dwellers in Spain.Brain and behavior · 2026Article
- rsfMRI-based brain entropy is negatively correlated with gray matter volume and surface area.Brain structure & function · 2025Article
- A Bidirectional Mendelian Randomization Study of Causal Relationships Between Migraine and White-Matter Structural Connectivity.Journal of pain research · 2025Article
- Effects of traditional Chinese exercises on brain-derived neurotrophic factor in middle-aged and older adults: A systematic review and meta-analysis of randomized controlled trials.Journal of exercise science and fitness · 2025Review
- Brain structural alterations in vestibular schwannoma beyond tinnitus and hearing loss.Brain communications · 2025Article
- Structural and functional sex differences in medial temporal lobe subregions at midlife.BMC neuroscience · 2024Article
- The uniqueness of human vulnerability to brain aging in great ape evolution.Science advances · 2024Article
- Physical exercise and cognition in older adults, a scientific approach scanty reported in Latin America and Caribbean populations.Frontiers in sports and active living · 2024Article
- Sex differences in human brain networks in normal and psychiatric populations from the perspective of small-world properties.Frontiers in psychiatry · 2024Review
- Aging exerts a limited influence on the perception of self-generated and externally generated touch.Journal of neurophysiology · 2023Article
- Longitudinal changes in gray matter correspond to changes in cognition across the lifespan: implications for theories of cognition.Neurobiology of aging · 2023Article
- Cross-sectional associations between cortical thickness and physical activity in older adults with spontaneous memory complaints: The MAPT Study.Journal of sport and health science · 2023Article
- Evaluating the causal effect of tobacco smoking on white matter brain aging: a two-sample Mendelian randomization analysis in UK Biobank.Addiction (Abingdon, England) · 2023Article
- Causal relationships between migraine and microstructural white matter: a Mendelian randomization study.The journal of headache and pain · 2023Article
- Age- and sex-related differences in cortical morphology and their relationships with cognitive performance in healthy middle-aged and older adults.Quantitative imaging in medicine and surgery · 2023Article
- Development and validation of deep learning-based automatic brain segmentation for East Asians: A comparison with Freesurfer.Frontiers in neuroscience · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Brain structural morphology differs with age. This study examined age-differences in surface-based morphometric measures of cortical thickness, volume, and surface area in a well-defined sample of 8137 generally healthy UK Biobank participants aged 45-79 years. We illustrate that the complexity of age-related brain morphological differences may be related to the laminar organization and regional evolutionary history of the cortex, and age of about 60 is a break point for increasing negative associations between age and brain morphology in Alzheimer's disease (AD)-prone areas. We also report novel relationships of age-related cortical differences with individual factors of sex, cognitive functions of fluid intelligence, reaction time and prospective memory, cigarette smoking, alcohol consumption, sleep disruption, genetic markers of apolipoprotein E, brain-derived neurotrophic factor, catechol-O-methyltransferase, and several genome-wide association study loci for AD and further reveal joint effects of cognitive functions, lifestyle behaviors, and education on age-related cortical differences. These findings provide one of the most extensive characterizations of age associations with major brain morphological measures and improve our understanding of normal structural brain aging and its potential modifiers.
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