ArticleCerebral cortex (New York, N.Y. : 1991)2019
Emergence of Coordinated Activity in the Developing Entorhinal-Hippocampal Network.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 55 citations in OpenAlex.
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- Dual inhibition of MAPK/ERK and BMP signaling induces entorhinal-like identity in mouse ESC-derived pallial progenitors.Stem cell reports · 2025Article
- Reverse engineering of feedforward cortical-Hippocampal microcircuits for modelling neural network function and dysfunction.Scientific reports · 2024Article
- Chemogenetic silencing reveals presynaptic GiScience · 2024Article
- Network state transitions during cortical development.Nature reviews. Neuroscience · 2024Review
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- A developmental increase of inhibition promotes the emergence of hippocampal ripples.Nature communications · 2024Article
- Synchronous excitation in the superficial and deep layers of the medial entorhinal cortex precedes early sharp waves in the neonatal rat hippocampus.Frontiers in cellular neuroscience · 2024Article
- Somatosensory-Evoked Early Sharp Waves in the Neonatal Rat Hippocampus.International journal of molecular sciences · 2023Article
- Insulin-Like Growth Factor-1 Supplementation Promotes Brain Maturation in Preterm Pigs.eNeuro · 2023Article
- The rapid developmental rise of somatic inhibition disengages hippocampal dynamics from self-motion.eLife · 2022Article
- Step by step: cells with multiple functions in cortical circuit assembly.Nature reviews. Neuroscience · 2022Review
- Review
- A limited role of NKCC1 in telencephalic glutamatergic neurons for developing hippocampal network dynamics and behavior.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Processing of Hippocampal Network Activity in the Receiver Network of the Medial Entorhinal Cortex Layer V.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- GABAergic interneurons excite neonatal hippocampus in vivo.Science advances · 2020Article
- THE DEVELOPING BRAIN REVEALED DURING SLEEP.Current opinion in physiology · 2020Article
- Active Sleep Promotes Coherent Oscillatory Activity in the Cortico-Hippocampal System of Infant Rats.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Correlated activity in the entorhinal-hippocampal neuronal networks, supported by oscillatory and intermittent population activity patterns is critical for learning and memory. However, when and how correlated activity emerges in these networks during development remains largely unknown. Here, we found that during the first postnatal week in non-anaesthetized head-restrained rats, activity in the superficial layers of the medial entorhinal cortex (MEC) and hippocampus was highly correlated, with intermittent population bursts in the MEC followed by early sharp waves (eSPWs) in the hippocampus. Neurons in the superficial MEC layers fired before neurons in the dentate gyrus, CA3 and CA1. eSPW current-source density profiles indicated that perforant/temporoammonic entorhinal inputs and intrinsic hippocampal connections are co-activated during entorhinal-hippocampal activity bursts. Finally, a majority of the entorhinal-hippocampal bursts were triggered by spontaneous myoclonic body movements, characteristic of the neonatal period. Thus, during the neonatal period, activity in the entorhinal cortex (EC) and hippocampus is highly synchronous, with the EC leading hippocampal activation. We propose that such correlated activity is embedded into a large-scale bottom-up circuit that processes somatosensory feedback resulting from neonatal movements, and that it is likely to instruct the development of connections between neocortex and hippocampus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.