Evidence map›Paper›PMID 30534599›Full record

ArticlemSystems

New Insights into Human Nostril Microbiome from the Expanded Human Oral Microbiome Database (eHOMD): a Resource for the Microbiome of the Human Aerodigestive Tract.

Isabel F Escapa, Tsute Chen, Yanmei Huang, Prasad Gajare, Floyd E Dewhirst, Katherine P Lemon

Abstract read
In one paragraph

Article in mSystems. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 381 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
381citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

381 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Article
  10. Article
  11. The Oral Microbiome of King Richard III of England.American journal of biological anthropology · 2026
    Article
  12. Review
  13. Observational
  14. Article
  15. Article
  16. Review
  17. Article
  18. Human Oral-AssociatedMicroorganisms · 2026
    Review
  19. Pangenomes of the human oral microbiome.Microbiology resource announcements · 2026
    Article
  20. Article

321 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Isabel F EscapaThe Forsyth Institute (Microbiology), Cambridge, Massachusetts, USA.
Tsute Chen *The Forsyth Institute (Microbiology), Cambridge, Massachusetts, USA.
Yanmei Huang *The Forsyth Institute (Microbiology), Cambridge, Massachusetts, USA.
Prasad GajareThe Forsyth Institute (Microbiology), Cambridge, Massachusetts, USA.
Floyd E DewhirstThe Forsyth Institute (Microbiology), Cambridge, Massachusetts, USA.
Katherine P LemonThe Forsyth Institute (Microbiology), Cambridge, Massachusetts, USA.

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
Mouse Oral Microbiome DatabaseR37DE016937 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI DEWHIRST, FLOYD E · 2011 to 2020
$8.6M
Cultivation, Nature, Ecology and Pathogenicity of the Uncultivable Oral MicrobiomR01DE024468 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI ALM, ERIC JOHN, DEWHIRST, FLOYD E · 2014 to 2018
$7.3M
Cloud-Based Machine Learning and Biomarker Visual Analytics for Salivary ProteomicsR01DE016937 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI DEWHIRST, FLOYD E, MARK WELCH, JESSICA LEIGH · 2021 to 2025
$6.7M
Antibiotics from nose and throat commensals that impact pathogen colonizationR01AI101018 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI FISCHBACH, MICHAEL ANDREW, LEMON, KATHERINE PAIGE · 2012 to 2021
$4.4M
Impact of Commensal Corynebacterium Species on Pathogen Colonization and Microbiota CompositionR01GM117174 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI LEMON, KATHERINE PAIGE · 2016 to 2019
$1.5M
NCATS NIH HHS UL1 TR001102NIAID NIH HHS R01 AI101018NIDCR NIH HHS R01 DE016937NIDCR NIH HHS R01 DE024468NIDCR NIH HHS R37 DE016937NIGMS NIH HHS R01 GM117174
6 · The paper itself

Abstract

The expanded Human Oral Microbiome Database (eHOMD) is a comprehensive microbiome database for sites along the human aerodigestive tract that revealed new insights into the nostril microbiome. The eHOMD provides well-curated 16S rRNA gene reference sequences linked to available genomes and enables assignment of species-level taxonomy to most next-generation sequences derived from diverse aerodigestive tract sites, including the nasal passages, sinuses, throat, esophagus, and mouth. Using minimum entropy decomposition coupled with the RDP Classifier and our eHOMD V1-V3 training set, we reanalyzed 16S rRNA V1-V3 sequences from the nostrils of 210 Human Microbiome Project participants at the species level, revealing four key insights. First, we discovered that Lawsonella clevelandensis, a recently named bacterium, and

Indexed as

16SCorynebacteriumDolosigranulumLawsonellamicrobiotanaresnasalrespiratory tractsinusStaphylococcus

Identifiers

PMID30534599
PMCPMC6280432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.