Evidence map›Paper›PMID 30534561›Full record

ArticleBioMed research international2018

Testing Pathological Variation of White Matter Tract in Adult Rats after Severe Spinal Cord Injury with MRI.

Wei Song, Guiyun Song, Can Zhao, Xiaoguang Li, Xiaojiao Pei, Wen Zhao, Yudan Gao, Jia-Sheng Rao, Hongmei Duan, Zhaoyang Yang

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Brain & spine · 2022
    Review
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Wei SongCapital Medical University School of Rehabilitation Medicine, Beijing 100068, China.
Guiyun SongCapital Medical University School of Rehabilitation Medicine, Beijing 100068, China.
Can ZhaoBeijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100083, China.
Xiaoguang LiDepartment of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Xiaojiao PeiDepartment of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Wen ZhaoDepartment of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Yudan GaoDepartment of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Jia-Sheng RaoBeijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100083, China.ORCID 0000-0002-5196-0912
Hongmei DuanDepartment of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.ORCID 0000-0003-2261-2182
Zhaoyang YangDepartment of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.ORCID 0000-0001-8313-6998
Capital Medical University · CNBeijing Advanced Sciences and Innovation Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to assess the pathological variation in white matter tracts in the adult severe thoracic contusion spinal cord injury (SCI) rat models combined with in vivo magnetic resonance imaging (MRI), as well as the effect of spared white matter (WM) quantity on hindlimb motor function recovery. 7.0T MRI was conducted for all experimental animals before SCI and 1, 3, 7, and 14 days after SCI. The variation in the white matter tract in different regions of the spinal cord after SCI was examined by luxol fast blue (LFB) staining, NF200 immunochemistry, and diffusion tensor imaging (DTI) parameters, including fraction anisotropy, mean diffusivity, axial diffusion, and radial diffusivity. Meanwhile, Basso-Beattie-Bresnahan (BBB) open-field scoring was performed to evaluate the behavior of the paraplegic hind limbs. The quantitative analysis showed that spared white matter measures assessed by LFB and MRI had a close correlation (R

Indexed as

Magnetic Resonance ImagingAnimalsAnisotropyAxonsBlood-Brain BarrierDiffusion Tensor ImagingFemaleHindlimbMotor ActivityMyelin SheathNeurofilament ProteinsRats, WistarRecovery of FunctionSpinal Cord InjuriesStaining and LabelingTime Factorsneurofilament protein HNeurofilament Proteins

Identifiers

PMID30534561
PMCPMC6252222
OpenAlexW2900001682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.