ArticlePlastic and reconstructive surgery. Global open2018
Surgical Algorithm for Neuroma Management: A Changing Treatment Paradigm.
Article in Plastic and reconstructive surgery. Global open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05344261 (Prophylactic Treatment of Neuroma and Phantom Limb Pain With Targeted Muscle Reinnervation), which is not on this map. Cited by 78 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prophylactic Treatment of Neuroma and Phantom Limb Pain With Targeted Muscle Reinnervation (TMR) and Regenerative Peripheral Interface (RPNI) at the Time of Major Limb Amputation: A Randomized Control Trial
Who cites it
78 citing papers in PubMed, 204 citations in OpenAlex.
- Painful neuromas exhibit axonal phenotypic shift via nociceptive and mechanosensitive marker up-regulation.PNAS nexus · 2026Article
- Regenerative Peripheral Nerve Interface (RPNI) and vascularized Denervated Muscle Targets (VDMT): a preclinical rabbit model as a translational feasibility and methodological platform.Journal of translational medicine · 2026Article
- Algorithm for Surgical Management of Symptomatic Hand and Digital Neuromas.Plastic and reconstructive surgery. Global open · 2026Article
- Article
- A Novel Hydrogel for Treatment and Prevention of Symptomatic Neuroma: Early Clinical Experience.Plastic and reconstructive surgery. Global open · 2025Article
- Surgical Outcomes in Non-Transected and Partially Transected Peripheral Nerve Injuries.Brain sciences · 2025Review
- Outcomes of Ertl Osteomyoplasty Transtibial Amputation With Primary Targeted Muscle Reinnervation and Regenerative Peripheral Nerve Interface.Plastic and reconstructive surgery. Global open · 2025Article
- Necrotizing Fasciitis and Targeted Muscle Reinnervation in the Upper Extremity: A Case Report.The American journal of case reports · 2025Article
- Pedicled adipofascial flaps for treatment and prophylaxis of neurodesis and neuromas in continuity of the upper extremity: A case series of 22 patients.Journal of hand and microsurgery · 2025Article
- Orthoplastic Approach to Extremity Reconstruction: A Paradigm Shift in Integrated Limb Salvage.Seminars in plastic surgery · 2025Review
- Lower Extremity Targeted Muscle Reinnervation for Mononeuropathy in Nonamputation Patients: Techniques and Tips.Plastic and reconstructive surgery. Global open · 2025Article
- Surgical management of peripheral nerve symptoms following knee arthroplasty.Arthroplasty (London, England) · 2025Article
- Targeted Muscle Reinnervation-an Up-to-Date Review: Evidence, Indications, and Technique.Archives of plastic surgery · 2025Article
- Effect of Intercostal Nerve Coaptation on Postoperative Pain in Implant-Based Breast Reconstruction: A Double-Blind, Randomized Controlled Pilot Study.Journal of breast cancer · 2025Article
- The Recurrence of Painful Neuromas of the Limbs Following TMR.Journal of clinical medicine · 2025Article
- Article
- Treatment of Phantom and Residual Limb Pain in Amputees With Targeted Muscle Reinnervation.Eplasty · 2025Article
- Clinically Reducing/Eliminating Chronic Neuropathic Pain by Bridging Peripheral Nerve Gaps with an Autograft within a PRP-Filled Collagen Tube.Journal of pain research · 2025Article
- Traumatic neuroma of the medial antebrachial cutaneous nerve treated by targeted muscle reinnervation using the epitrochleoanconeus muscle.Clinical case reports · 2024Article
- Surgical Outcomes of Spiral Vein Wrapping Flaps for Painful Neuromas: A Case Series Analysis.The American journal of case reports · 2024Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Successful treatment of the painful neuroma is a particular challenge to the nerve surgeon. Historically, symptomatic neuromas have primarily been treated with excision and implantation techniques, which are inherently passive and do not address the terminal end of the nerve. Over the past decade, the surgical management of neuromas has undergone a paradigm shift synchronous with the development of contemporary techniques aiming to satisfy the nerve end. In this article, we describe the important features of surgical treatment, including the approach to diagnosis with consideration of neuroma type and the decision of partial versus complete neuroma excision. A comprehensive list of the available surgical techniques for management following neuroma excision is presented, the choice of which is often predicated upon the availability of the terminal nerve end for reconstruction. Techniques for neuroma reconstruction in the presence of an intact terminal nerve end include hollow tube reconstruction and auto- or allograft nerve reconstruction. Techniques for neuroma management in the absence of an intact or identifiable terminal nerve end include submuscular or interosseous implantation, centro-central neurorrhaphy, relocation nerve grafting, nerve cap placement, use of regenerative peripheral nerve interface, "end-to-side" neurorrhaphy, and targeted muscle reinnervation. These techniques can be further categorized into passive/ablative and active/reconstructive modalities. The nerve surgeon must be aware of available treatment options and should carefully choose the most appropriate intervention for each patient. Comparative studies are lacking and will be necessary in the future to determine the relative effectiveness of each technique.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.