Evidence map›Paper›PMID 30534124›Full record

ArticleFrontiers in immunology2018

Lipocalin-2 Functions as Inhibitor of Innate Resistance to

Sara Louise Dahl, Joshua S Woodworth, Christian Johann Lerche, Elisabeth Præstekjær Cramer, Pia Rude Nielsen, Claus Moser, Allan Randrup Thomsen, Niels Borregaard, Jack Bernard Cowland

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Meta-analysis reveals a core iron-responsive gene signature in Mycobacterium tuberculosis linking siderophore biosynthesis, virulence, and metabolic adaptation.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Pooled it
  2. Observational
  3. Article
  4. In defence of ferroptosis.Signal transduction and targeted therapy · 2025
    Review
  5. Review
  6. Article
  7. TargetingRSC medicinal chemistry · 2023
    Review
  8. The regulation of TRPA1 expression and function by Th1 and Th2-type inflammation in human A549 lung epithelial cells.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Article
  9. Psoriasis and Leprosy: An Arcane Relationship.Journal of inflammation research · 2023
    Article
  10. Article
  11. Review
  12. Comprehensive review of lipocalin 2-mediated effects in lung inflammation.American journal of physiology. Lung cellular and molecular physiology · 2021
    Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Changes in Transcript, Metabolite, and Antibody Reactivity During the Early Protective Immune Response in Humans to Mycobacterium tuberculosis Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  19. Towards new TB vaccines.Seminars in immunopathology · 2020
    Review
  20. The role of lipocalin-2 in age-related macular degeneration (AMD).Cellular and molecular life sciences : CMLS · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Sara Louise DahlGranulocyte Research Laboratory, Rigshospitalet, Copenhagen, Denmark.
Joshua S WoodworthDepartment of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark.
Christian Johann LercheDepartment of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.
Elisabeth Præstekjær CramerGranulocyte Research Laboratory, Rigshospitalet, Copenhagen, Denmark.
Pia Rude NielsenDepartment of Pathology, Zealand University Hospital, Roskilde, Denmark.
Claus MoserDepartment of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.
Allan Randrup ThomsenDepartment of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Niels BorregaardGranulocyte Research Laboratory, Rigshospitalet, Copenhagen, Denmark.
Jack Bernard CowlandGranulocyte Research Laboratory, Rigshospitalet, Copenhagen, Denmark.
Rigshospitalet · DKStatens Serum Institut · DKUniversity of Copenhagen · DKZealand University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipocalin-2 is a constituent of the neutrophil secondary granules and is expressed

Indexed as

Immunity, InnateAnimalsGranulocytesGranulomaLipocalin-2MacrophagesMiceMice, KnockoutMycobacterium tuberculosisTuberculosisLcn2 protein, mouseLipocalin-224p3innate immunityiron metabolismLcn2Mycobacterium tuberculosisneutrophilsNGAL

Identifiers

PMID30534124
PMCPMC6275245
OpenAlexW2902969332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.