Evidence map›Paper›PMID 30534086›Full record

ReviewFrontiers in physiology2018

Dental Pulp Stem Cell Mechanoresponsiveness: Effects of Mechanical Stimuli on Dental Pulp Stem Cell Behavior.

Massimo Marrelli, Bruna Codispoti, Richard M Shelton, Ben A Scheven, Paul R Cooper, Marco Tatullo, Francesco Paduano

Abstract readReview
In one paragraph

Review in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  15. Oscillatory fluid flow enhanced mineralization of human dental pulp cells.Frontiers in bioengineering and biotechnology · 2025
    Article
  16. Review
  17. Article
  18. Dentin Mechanobiology: Bridging the Gap between Architecture and Function.International journal of molecular sciences · 2024
    Review
  19. Article
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Massimo MarrelliStem Cells Unit, Biomedical Section, Tecnologica Research Institute and Marrelli Health, Crotone, Italy.
Bruna CodispotiStem Cells Unit, Biomedical Section, Tecnologica Research Institute and Marrelli Health, Crotone, Italy.
Richard M SheltonSchool of Dentistry, Institute of Clinical Sciences, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, United Kingdom.
Ben A SchevenSchool of Dentistry, Institute of Clinical Sciences, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, United Kingdom.
Paul R CooperSchool of Dentistry, Institute of Clinical Sciences, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, United Kingdom.
Marco TatulloStem Cells Unit, Biomedical Section, Tecnologica Research Institute and Marrelli Health, Crotone, Italy.
Francesco PaduanoStem Cells Unit, Biomedical Section, Tecnologica Research Institute and Marrelli Health, Crotone, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dental pulp is known to be an accessible and important source of multipotent mesenchymal progenitor cells termed dental pulp stem cells (DPSCs). DPSCs can differentiate into odontoblast-like cells and maintain pulp homeostasis by the formation of new dentin which protects the underlying pulp. DPSCs similar to other mesenchymal stem cells (MSCs) reside in a niche, a complex microenvironment consisting of an extracellular matrix, other local cell types and biochemical stimuli that influence the decision between stem cell (SC) self-renewal and differentiation. In addition to biochemical factors, mechanical factors are increasingly recognized as key regulators in DPSC behavior and function. Thus, microenvironments can significantly influence the role and differentiation of DPSCs through a combination of factors which are biochemical, biomechanical and biophysical in nature. Under

Indexed as

behaviordental pulp stem cells (DPSCs)mechanical propertiesmechanobiologymechanosensingsurface topography

Identifiers

PMID30534086
PMCPMC6275199

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.