Evidence map›Paper›PMID 30534073›Full record

ArticleFrontiers in pharmacology2018

A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans.

Sophie A Millar, Nicole L Stone, Andrew S Yates, Saoirse E O'Sullivan

3 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 284 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
284citing papers in PubMed, 5 pooled it
31.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04527003 phase3terminatednot on this mapstarted 2020, after this paper: background citation

A Randomized Controlled Pilot Study of the Use of Cannabidiol in the Management of Endometriosis Pain

TypeinterventionalSponsorMilton S. Hershey Medical CenterRan2020 to 2024Enrolled12ConditionsEndometriosis, CBD, Pelvic PainArmsCannabidiol (CBD) Extract, Norethindrone Acetate, Placebo
NCT04729179 phase3completednot on this mapstarted 2021, after this paper: background citation

Cannabidiol for Fibromyalgia -The CANNFIB Trial Protocol for a Randomized, Double-blind, Placebo-controlled, Parallel-group, Single-center Trial

TypeinterventionalSponsorMarius HenriksenRan2021 to 2024Enrolled200ConditionsFibromyalgiaArmsCannabidiol, Placebo
NCT06286839 nacompletednot on this mapstarted 2022, after this paper: background citation

An Open-Label Parallel Phase I Study Evaluating Multiple Ascending Dose Pharmacokinetics and Acute Immunomodulatory Potential of a Novel Oral Cannabidiol (CBD) Formulation

TypeinterventionalSponsorNextEvo Inc.Ran2022 to 2022Enrolled26ConditionsImmune System and Related Disorders, Immune System DiseasesArmsCannabidiol (CBD)
3 · Its place in the literature

Who cites it

284 citing papers in PubMed, 5 syntheses or guidelines pooled it, 526 citations in OpenAlex.

  1. Pooled it
  2. Guideline
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  4. The Role of Cannabidiol in Liver Disease: A Systemic Review.International journal of molecular sciences · 2024
    Pooled it
  5. Pooled it
  6. Trial
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  9. Does cannabidiol reduce the adverse effects of cannabis in schizophrenia? A randomised, double-blind, cross-over trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Trial
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  16. Effects of a cannabidiol/terpene formulation on sleep in individuals with insomnia: a double-blind, placebo-controlled, randomized, crossover study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Trial
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224 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sophie A MillarDivision of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham, Royal Derby Hospital, Derby, United Kingdom.
Nicole L StoneDivision of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham, Royal Derby Hospital, Derby, United Kingdom.
Andrew S YatesArtelo Biosciences, San Diego, CA, United States.
Saoirse E O'SullivanDivision of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham, Royal Derby Hospital, Derby, United Kingdom.
University of Nottingham · GBRoyal Derby Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

bioavailabilityCMAXendocannabinoid systemhalf lifepharmacokineticsplasma clearanceTMAXvolume of distribution

Identifiers

PMID30534073
PMCPMC6275223
OpenAlexW2902043534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.