Evidence map›Paper›PMID 30533520›Full record

ArticleAmerican journal of medical case reports2018

Brugada Pattern in Diabetic Ketoacidosis: A Case Report and Scoping Study.

Syed Haseeb, Pramod Theetha Kariyanna, Apoorva Jayarangaiah, Ganesh Thirunavukkarasu, Sudhanva Hegde, Jonathan D Marmur, Sneha Neurgaonkar, Samy I McFarlane

Open access · diamondAbstract read
In one paragraph

Article in American journal of medical case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Hyperkalemia-induced Brugada phenocopy: a systematic review of case reports.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Review
  4. Article
  5. Article
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  13. Article
  14. Brugada Syndrome: Warning of a Systemic Condition?Frontiers in cardiovascular medicine · 2021
    Review
  15. Article
  16. Diabetic ketoacidosis.Nature reviews. Disease primers · 2020
    Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Syed Haseeb *Division of Cardiovascular Disease and Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York, U.S.A- 11203.
Pramod Theetha Kariyanna *Division of Cardiovascular Disease and Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York, U.S.A- 11203.
Apoorva JayarangaiahDepartment of Internal Medicine, Wake Forest University, Baptist Health System, Winston-Salem, North Carolina, U.S.A-27157.
Ganesh ThirunavukkarasuDivision of Cardiovascular Disease and Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York, U.S.A- 11203.
Sudhanva HegdeDivision of Cardiovascular Disease and Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York, U.S.A- 11203.
Jonathan D MarmurDivision of Cardiovascular Disease and Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York, U.S.A- 11203.
Sneha NeurgaonkarDivision of Cardiovascular Disease and Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York, U.S.A- 11203.
Samy I McFarlaneDivision of Cardiovascular Disease and Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York, U.S.A- 11203.
State University of New York · USSUNY Downstate Health Sciences University · USBaptist Health System · US

Funding

TRANSPORT - the TRANSlational Program Of health disparities Research TrainingS21MD012474 · NIMHD · SUNY DOWNSTATE MEDICAL CENTER · PI Carla Boutin-Foster, William Marcus Lambert · 2017 to 2026
$18.0M
RESEARCH TRAINING/EDUCATION COREP20MD006875 · NIMHD · SUNY DOWNSTATE MEDICAL CENTER · PI BROWNE, RUTH C, FRASER, MARILYN · 2012 to 2016
$5.3M
NIMHD NIH HHS P20 MD006875
6 · The paper itself

Abstract

Brugada syndrome is a rare cardiac arrhythmia which is associated with right bundle branch block pattern (RBBB) and ST-segment elevation in right precordial leads. SCNA5 mutation is the most common genetic abnormality associated with Brugada syndrome. Brugada pattern not related to genetic mutations has been previously reported in the setting of fever, metabolic conditions, lithium use, marijuana and cocaine abuse, ischemia and pulmonary embolism, myocardial and pericardial diseases. Multiple isolated cases of Brugada pattern associated with diabetic ketoacidosis (DKA) have been previously reported. We here present a case of type 1 Brugada pattern in a 23 year-old-male who presented with DKA. Brugada pattern in DKA is attributed to acidosis and multiple electrolyte abnormalities including hyperkalemia which alter ion channel expression in the heart thus leading to Brugada pattern which subsequently resolved with treatment of DKA. In such patients, Brugada pattern is not reproducible on procainamide induction cardiac electrophysiology study (EPS). Our scoping study demonstrates male predominance 20/22 cases of (DELETE this highlighted area) Brugada pattern in DKA, a finding that is consistent with prevalence of this disease among males.

Indexed as

Brugada patterndiabetic ketoacidosis

Identifiers

PMID30533520
PMCPMC6282764
OpenAlexW2896091118

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.