Evidence map›Paper›PMID 30533517›Full record

ArticleAdvanced biosystems2018

In Vitro Microscale Models for Embryogenesis.

Jennifer Rico-Varela, Dominic Ho, Leo Q Wan

Open access · greenAbstract read
In one paragraph

Article in Advanced biosystems, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Rat embryonic stem cell-basedFrontiers in toxicology · 2025
    Article
  2. Article
  3. Biomedical applications of electrical stimulation.Cellular and molecular life sciences : CMLS · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jennifer Rico-VarelaDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy NY 12180.
Dominic HoDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy NY 12180.
Leo Q WanDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy NY 12180.
Rensselaer Polytechnic Institute · US

Funding

Cell Chirality Based In Vitro Models For Embryonic Development and AbnormalitiesDP2HD083961 · NICHD · RENSSELAER POLYTECHNIC INSTITUTE · PI WAN, LEO Q. · 2014 to 2016
$2.6M
NICHD NIH HHS DP2 HD083961
6 · The paper itself

Abstract

Embryogenesis is a highly regulated developmental process requiring complex mechanical and biochemical microenvironments to give rise to a fully developed and functional embryo. Significant efforts have been taken to recapitulate specific features of embryogenesis by presenting the cells with developmentally relevant signals. The outcomes, however, are limited partly due to the complexity of this biological process. Microtechnologies such as micropatterned and microfluidic systems, along with new emerging embryonic stem cell-based models, could potentially serve as powerful tools to study embryogenesis. The aim of this article is to review major studies involving the culturing of pluripotent stem cells using different geometrical patterns, microfluidic platforms, and embryo/embryoid body-on-a-chip modalities. Indeed, new research opportunities have emerged for establishing

Indexed as

Cell MicroenvironmentDevelopmentEmbryogenesisEmbryo-on-a-chipMicrofluidicsMicropatterningTeratogens

Identifiers

PMID30533517
PMCPMC6286056
OpenAlexW2801388743

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.