SynthesisBioMed research international2018
Tranexamic Acid for Adults with Melasma: A Systematic Review and Meta-Analysis.
Synthesis in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- The Efficacy of Laser Therapy in Melasma Treatment: A Systematic Review and Meta-Analysis.Journal of cosmetic dermatology · 2025Pooled it
- Exploring the Effectiveness, Tolerability, and Safety of the Adjunctive Use of Microneedling With Tranexamic Acid in the Treatment of Melasma.Journal of cosmetic dermatology · 2026Review
- Systematic Review and Meta-Analysis of Treatments on Melasma Area Severity Index and Quality of Life.Pharmaceutics · 2025Review
- Effectiveness and Safety of Intradermal Tranexamic Acid Injection as an Adjunctive Treatment for Melasma in Skin Type IV-V: A Double-blind Randomized Controlled Trial.The Journal of clinical and aesthetic dermatology · 2025Article
- Article
- Uses of tranexamic acid and the risk of thrombosis in women: Number 11 - 2025.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025Article
- Amber photobiomodulation versus tranexamic acid for the treatment of melasma: protocol for a double-blind, randomised controlled trial.BMJ open · 2023Article
- Mesotherapy-Induced Cutaneous Foreign Body-Type Granulomatous Reaction in the Face Treated with Minocycline: Case Report and Literature Review.Clinical, cosmetic and investigational dermatology · 2023Article
- Split-face comparative study between intradermal tranexamic acid injection alone versus intradermal tranexamic acid injection combined with Q-switched Nd:YAG laser in melasma treatment: dermoscopic and clinical evaluation.Lasers in medical science · 2022Article
- Tranexamic acid reduces endometrial cancer effects through the production of angiostatin.Journal of Cancer · 2022Article
- Therapeutic Effect of Microneedling with Platelet-rich Plasma Versus Microneedling with Tranexamic Acid for Melasma.The Journal of clinical and aesthetic dermatology · 2021Article
- Short Practical Regimen of Acupuncture for Melasma: A Prospective Cohort Study in a Tertiary Hospital in Thailand.Frontiers in public health · 2021Observational
- Comparison of the Efficacy of Intradermal Tranexamic Acid and Topical Triple Combination Modification in Decreasing the Severity Score of Melasma: A Meta-analysis.Indian journal of dermatologyReview
- Comparison of efficacy of Tranexamic Acid Mesotherapy versus 0.9% normal Saline for Melasma; A split face study in a Tertiary Care Hospital of Karachi.Pakistan journal of medical sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMelasma is a highly prevalent, chronic, and pigmentary disorder. This systematic review aims to evaluate the efficacy and safety of tranexamic acid (TA) for the treatment of adults with melasma.
methodsWe independently searched 3 databases from beginning to 26 April, 2018. The study included 21 eligible trials. Two writers extracted data at the same time independently. Study outcomes were calculated by standardized mean differences (SMD) with 95% confidence intervals (CIs). All statistical analyses were performed using Review Manager Version 5.3 and STATA Version 15.1.
resultsThe combined results showed that the use of TA was associated with reduced Melasma Area and Severity Index (MASI) and Melanin Index (MI). No significant difference in Erythema Index (EI) was observed with TA treatment. Side effects were minor, with a few cases reporting mild gastrointestinal reaction, oligomenorrhoea, hypopigmentation, urticarial rash, and skin irritation xerosis.
conclusionThe meta-analysis suggested that TA treatment appeared to be a promising therapeutic approach for melasma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.