ArticleFrontiers in cellular and infection microbiology2018
Potential Pandemic of H7N9 Avian Influenza A Virus in Human.
Article in Frontiers in cellular and infection microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 24 citations in OpenAlex.
- Predicting host tropism in influenza a viruses: insights from multi-segment nucleotide signatures.Journal of translational medicine · 2025Article
- The emergence of highly pathogenic avian influenza H5N1 in dairy cattle: implications for public health, animal health, and pandemic preparedness.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Review
- Avian Influenza Virus: Comparative Evolution as the Key for Predicting Host Tropism Expansion.Pathogens (Basel, Switzerland) · 2025Article
- Adaptive selection of quasispecies duringJournal of virology · 2025Article
- Bayesian phylodynamics reveals the transmission dynamics of avian influenza A(H7N9) virus at the human-live bird market interface in China.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Avian Influenza Virus Tropism in Humans.Viruses · 2023Review
- H7N9 Influenza Virus in China.Cold Spring Harbor perspectives in medicine · 2021Review
- Optimizing the early detection of low pathogenic avian influenza H7N9 virus in live bird markets.Journal of the Royal Society, Interface · 2021Article
- Molecular Characterization of Closely Related H6N2 Avian Influenza Viruses Isolated from Turkey, Egypt, and Uganda.Viruses · 2021Article
- Development and application of reverse genetic technology for the influenza virus.Virus genes · 2021Review
- Bat Influenza Viruses: Current Status and Perspective.Viruses · 2021Review
- Host Adaptive Evolution of Avian-Origin H3N2 Canine Influenza Virus.Frontiers in microbiology · 2021Article
- The effect of mutations derived from mouse-adapted H3N2 seasonal influenza A virus to pathogenicity and host adaptation.PloS one · 2020Article
- Avian influenza overview November 2018 - February 2019.EFSA journal. European Food Safety Authority · 2019Article
- Mutations in the H7 HA and PB1 genes of avian influenza a viruses increase viral pathogenicity and contact transmission in guinea pigs.Emerging microbes & infections · 2019Article
- Enhancing Immune Response and Heterosubtypic Protection Ability of Inactivated H7N9 Vaccine by Using STING Agonist as a Mucosal Adjuvant.Frontiers in immunology · 2019Article
- Evolutionary dynamics of the H7N9 avian influenza virus based on large-scale sequence analysis.PloS one · 2019Article
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since 2013, the H7N9 avian influenza A virus (AIV) has caused human infections and to the extent of now surpassing H5N1. This raises an alarm about the potential of H7N9 to become a pandemic problem. Our compilation of the amino acid changes required for AIVs to cross the species-barrier discovers 58 that have very high proportions in both the human- and avian-isolated H7N9 viruses. These changes correspond with sporadic human infections that continue to occur in regions of avian infections. Among the six internal viral genes, amino acid changes do not differ significantly between H9N2 and H7N9, except for V100A in PA, and K526R, D627K, and D701N in PB2. H9N2 AIVs provide internal genes to H7N9. Most of the amino acid changes in H7N9 appear to come directly from H9N2. Seventeen amino acid substitutions appear to have fixed quickly by the 5th wave. Among these, six amino acid sites in HA1 are receptor binding sites, and PB2-A588V was shown to promote the adaptation of AIVs to mammals. The accelerated fixation of mutations may promote the adaptation of H7N9 to human, but need further functional evidence. Although H7N9 AIVs still cannot efficiently transmit between humans, they have the genetic makeup associated with human infections. These viruses must be controlled in poultry to remove the threat of it becoming a human pandemic event.
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