ReviewBio-design and manufacturing2018
Osteochondral tissue repair in osteoarthritic joints: clinical challenges and opportunities in tissue engineering.
Review in Bio-design and manufacturing, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Potential of periosteal cells in bone and cartilage regeneration: a systematic review.Frontiers in bioengineering and biotechnology · 2023Pooled it
- Usefulness of Mesenchymal Cell Lines for Bone and Cartilage Regeneration Research.International journal of molecular sciences · 2019Pooled it
- The 3D printed biphasic scaffolds incorporating epimedin C promotes osteochondral regeneration in osteoarthritis rats.Regenerative biomaterials · 2026Article
- Personalized Design of 3D-Printed Osteochondral Scaffold for Osteoarthritis Patients with Different Bone Conditions and Mechanical Evaluation.Bioengineering (Basel, Switzerland) · 2025Article
- Dialdehyde Starch Cross-Linked Collagen with Heparin Conjugation: Characterization and Feasibility Study for Osteochondral Tissue Repair.Gels (Basel, Switzerland) · 2025Article
- Immunomodulatory biomaterials for osteoarthritis: Targeting inflammation and enhancing cartilage regeneration.Materials today. Bio · 2025Review
- Relationship between knee pain and depth-specific measures of proximal tibial subchondral bone density.Osteoarthritis and cartilage · 2025Article
- Decellularized cartilage tissue bioink formulation for osteochondral graft development.Biomedical materials (Bristol, England) · 2025Article
- Biomimetic multizonal scaffolds for the reconstruction of zonal articular cartilage in chondral and osteochondral defects.Bioactive materials · 2025Review
- Development of Small Molecular Drug-Loaded Microspheres for Enhanced Cartilage Regeneration.Journal of stem cells & regenerative medicine · 2025Article
- Design and Characterization of Biomimetic Hybrid Construct Based on Hyaluronic Acid and Alginate Bioink for Regeneration of Articular Cartilage.Pharmaceutics · 2024Article
- Tribomechanical Properties of PVA/NomexGels (Basel, Switzerland) · 2024Article
- Fabrication Method for Shape-Controlled 3D Tissue Using High-Porosity Porous Structure.Bioengineering (Basel, Switzerland) · 2024Article
- A 4D printed self-assembling PEGDA microscaffold fabricated by digital light processing for arthroscopic articular cartilage tissue engineering.Progress in additive manufacturing · 2024Article
- Antioxidant hydrogels for the treatment of osteoarthritis: mechanisms and recent advances.Frontiers in pharmacology · 2024Review
- Small-Molecule Loaded Biomimetic Biphasic Scaffold for Osteochondral Regeneration: An In Vitro and In Vivo Study.Bioengineering (Basel, Switzerland) · 2023Article
- Article
- Osteochondral regenerative engineering: challenges, state-of-the-art and translational perspectives.Regenerative biomaterials · 2023Review
- Biomechanical Aspects of Osteochondral Regeneration: Implications and Strategies for Three-Dimensional Bioprinting.Tissue engineering. Part B, Reviews · 2022Review
- Computational investigation of interface printing patterns within 3D printed multilayered scaffolds for osteochondral tissue engineering.Biofabrication · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis (OA), identified as one of the priorities for the Bone and Joint Decade, is one of the most prevalent joint diseases, which causes pain and disability of joints in the adult population. Secondary OA usually stems from repetitive overloading to the osteochondral (OC) unit, which could result in cartilage damage and changes in the subchondral bone, leading to mechanical instability of the joint and loss of joint function. Tissue engineering approaches have emerged for the repair of cartilage defects and damages to the subchondral bone in the early stages of OA and have shown potential in restoring the joint's function. In this approach, the use of three-dimensional scaffolds (with or without cells) provides support for tissue growth. Commercially available OC scaffolds have been studied in OA patients for repair and regeneration of OC defects. However, none of these scaffolds has shown satisfactory clinical results. This article reviews the OC tissue structure and the design, manufacturing and performance of current OC scaffolds in treatment of OA. The findings demonstrate the importance of biological and biomechanical fixations of OC scaffolds to the host tissue in achieving an improved cartilage fill and a hyaline-like tissue formation. Achieving a strong and stable subchondral bone support that helps the regeneration of overlying cartilage seems to be still a grand challenge for the early treatment of OA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.