Evidence map›Paper›PMID 30533218›Full record

ArticleJournal of transplantation2018

Temporal Changes on the Risks and Complications of Posttransplantion Diabetes Mellitus Following Cardiac Transplantation.

Nadia Iannino, Amine Nasri, Agnès Räkel, Anique Ducharme, Kim Lachance, Normand Racine, Simon de Denus, Maxime Tremblay-Gravel, Annik Fortier, Michel White

Open access · goldAbstract read
In one paragraph

Article in Journal of transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Nadia IanninoMontreal Heart Institute, Université de Montréal, Montreal, QC, Canada.
Amine NasriMontreal Heart Institute, Université de Montréal, Montreal, QC, Canada.
Agnès RäkelCentre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.
Anique DucharmeMontreal Heart Institute, Université de Montréal, Montreal, QC, Canada.
Kim LachanceSanofi Canada, Laval, QC, Canada.
Normand RacineMontreal Heart Institute, Université de Montréal, Montreal, QC, Canada.
Simon de DenusMontreal Heart Institute, Université de Montréal, Montreal, QC, Canada.
Maxime Tremblay-GravelMontreal Heart Institute, Université de Montréal, Montreal, QC, Canada.
Annik FortierMontreal Health Innovations Coordinating Center, Montreal, QC, Canada.
Michel WhiteMontreal Heart Institute, Université de Montréal, Montreal, QC, Canada.ORCID 0000-0002-7945-1343
Montreal Heart Institute · CACentre Hospitalier de l’Université de Montréal · CASanofi (Canada) · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent changes in the demographic of cardiac donors and recipients have modulated the rate and risk, associated with posttransplant diabetes mellitus (PTDM). We investigated the secular trends of the risk of PTDM at 1 year and 3 years after transplantation over 30 years and explored its effect on major outcomes.

methodsThree hundred and three nondiabetic patients were followed for a minimum of 36 months, after a first cardiac transplantation performed between 1983 and 2011. Based on the year of their transplantation, the patients were divided into 3 eras: (1983-1992 [era 1], 1993-2002 [era 2], and 2003-2011 [era 3]).

resultsIn eras 1, 2, and 3, the proportions of patients with PTDM at 1 versus 3 years were 23% versus 39%, 21% versus 26%, and 33% versus 38%, respectively. Independent risk factors predicting PTDM at one year were recipient's age, duration of cold ischemic time, treatment with furosemide, and tacrolimus. There was a trend for overall survival being worse for patients with PTDM in comparison to patients without PTDM (

conclusionThe development of PTDM following cardiac transplantation approaches 40% at 3 years and has not significantly changed over thirty years. The presence of PTDM is weakly associated with an increased mortality and is significantly associated with a worsening in renal function long-term following cardiac transplantation.

Identifiers

PMID30533218
PMCPMC6250037
OpenAlexW2899820900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.