ArticlePloS one2018
An increase in mean platelet volume during admission can predict the prognoses of patients with pneumonia in the intensive care unit: A retrospective study.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Mean platelet volume as a translational biomarker for cardiovascular risk stratification with perspectives for medical education: a systematic review.Global cardiology science & practice · 2026Review
- Clinical values of preoperative red blood cell distribution width and platelet parameters in patients with papillary thyroid carcinoma.Oncology letters · 2024Article
- The association between mean platelet volume and poor outcome in patients with COVID-19: Systematic review, meta-analysis, and meta-regression.Journal of the Intensive Care Society · 2023Article
- Platelet Abnormalities in Children with Laboratory-Confirmed Influenza.Diagnostics (Basel, Switzerland) · 2023Article
- Dynamic changes in the migratory microbial components of colon tissue during different periods of sepsis in an LPS-induced rat model.Frontiers in cellular and infection microbiology · 2023Article
- Mean platelet volume as a predictive biomarker for in-hospital mortality in patients receiving invasive mechanical ventilation.BMC pulmonary medicine · 2022Observational
- Response to the Letter: Mean Platelet Volume and Related Parameters May Not Contribute to the Diagnosis in Patients with Ascending Thoracic Aortic Aneurysm.Brazilian journal of cardiovascular surgery · 2022Article
- Predicting acute respiratory distress syndrome in influenza pneumonia patients using delta mean platelet volume.BMC pulmonary medicine · 2021Article
- EVALUATION OF THE RELATIONSHIP OF MPV, RDW AND PVI PARAMETERS WITH DISEASE SEVERITY IN COVID-19 PATIENTS.Acta clinica Croatica · 2021Article
- Mean platelet volume/platelet count ratio predicts severe pneumonia of COVID-19.Journal of clinical laboratory analysis · 2021Article
- Clinical manifestation, laboratory and radiology finding, treatment and outcomes of COVID-19: A systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Review
- Response to the Letter: Mean Platelet Volume to Platelet Count Value May Not Be a Prognostic Marker in Patients with Crimean-Congo Hemorrhagic Fever.Rambam Maimonides medical journal · 2020Article
- Evaluation of Immature Platelet Fraction in Lower Respiratory Tract Infections: A Retrospective Study.Cureus · 2020Article
- Reduced miR-26b Expression in Megakaryocytes and Platelets Contributes to Elevated Level of Platelet Activation Status in Sepsis.International journal of molecular sciences · 2020Article
- Platelets and Their Role in the Pathogenesis of Cardiovascular Events in Patients With Community-Acquired Pneumonia.Frontiers in immunology · 2020Review
- Article
- High Mean Platelet Volume Associates with In-Hospital Mortality in Severe Pneumonia Patients.Mediators of inflammation · 2020Article
- Absolute Neutrophil Count and Mean Platelet Volume in the Blood as Biomarkers to Detect Lung Cancer.Disease markers · 2020Article
- Changes in and significance of platelet function and parameters in Kawasaki disease.Scientific reports · 2019Article
- Prognostic Significance Of Platelet-To-Lymphocyte Ratio (PLR) And Mean Platelet Volume (MPV) During Etoposide-Based First-Line Treatment In Small Cell Lung Cancer Patients.Cancer management and research · 2019Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Platelets play an important role in hemostasis, inflammation, and immunity. Mean platelet volume (MPV), considered a marker of platelet function and activation, is associated with increased morbidity and mortality in sepsis, coronary artery disease, and chronic inflammatory disease. However, the clinical characteristics and prognostic significance of MPV changes for patients with pneumonia in the intensive care unit (ICU) have not been investigated. This retrospective study was conducted using data from an operational database of patients admitted to a medical ICU between October 2010 and October 2017. Of 235 adult patients with pneumonia admitted to the ICU, clinical characteristics and in-hospital mortality values were compared according to MPV, ΔMPVday1-2, ΔMPVday1-3, ΔMPVday1-4, and ΔMPVday1-Discharge between those who survived and those who did not. The MPV increased during the first four days for both non-survivors and survivors (P < 0.001). However, repeated measures analysis of variance revealed a significantly higher MPV rate over the first four days in non-survivors than in survivors. Additionally, the ΔMPVday1-2, ΔMPVday1-3, ΔMPVday1-4, and ΔMPVday1-Discharge values were significantly greater in non-survivors than in survivors. For in-hospital mortality, the optimal ΔMPV values were >0.9 fL, P = 0.020; >0.9 fL, P < 0.001; >0.8 fL, P < 0.001; and >1.3 fL, P < 0.001 on day 2, day 3, day 4, and at discharge, respectively. In conclusion, our findings demonstrate that ΔMPV during ICU admission may be used as a prognostic marker of mortality in ICU patients with pneumonia. Repeated MPV measurements throughout hospitalization may improve risk stratification for these patients, which could aid in improving patient outcomes.
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