ArticlePloS one2018
Genome-wide identification and functional analysis of circRNAs in Zea mays.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- The evolving landscape of chronic pancreatitis in Japan: findings from a nationwide epidemiological survey in 2021.Journal of gastroenterology · 2026Article
- A comprehensive landscape of theFrontiers in plant science · 2026Article
- MicroRNAs-mediated heat stress regulations in plants: Mechanisms and targets.The plant genome · 2025Review
- Maize transcriptome profiling reveals low temperatures affect photosynthesis during the emergence stage.Frontiers in plant science · 2025Article
- Review
- Identification and Characterisation of the CircRNAs Involved in the Regulation of Leaf Colour inBiology · 2024Article
- An accretive detection method for in silico identification and validation of circular RNAs in wheat (Triticum aestivum L.) using RT-qPCR.Molecular biology reports · 2024Article
- Whole-Transcriptome Sequencing Reveals the Global Molecular Responses and NAC Transcription Factors Involved in Drought Stress inAntioxidants (Basel, Switzerland) · 2024Article
- Identification and characterization of circular RNAs involved in the fertility stability of cotton CMS-D2 restorer line under heat stress.BMC plant biology · 2024Article
- LncRNAs exert indispensable roles in orchestrating the interaction among diverse noncoding RNAs and enrich the regulatory network of plant growth and its adaptive environmental stress response.Horticulture research · 2023Article
- Genome-wide identification and characterization of circRNAs in wheat tiller.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Identification and characterization of CircRNA-associated CeRNA networks in moso bamboo under nitrogen stress.BMC plant biology · 2023Article
- Identification, biogenesis, function, and mechanism of action of circular RNAs in plants.Plant communications · 2023Review
- Genome-Wide Characterization of Salt-Responsive miRNAs, circRNAs and Associated ceRNA Networks in Tomatoes.International journal of molecular sciences · 2021Article
- Identification and Characterization of Novel circRNAs Involved in Muscle Growth of Blunt Snout Bream (International journal of molecular sciences · 2021Article
- Novel circRNA discovery in sheep shows evidence of high backsplice junction conservation.Scientific reports · 2021Article
- Circular RNA derived from TIMP2 functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR‑185‑5p and matrix metalloproteinase 2.International journal of molecular medicine · 2020Article
- Systematic Identification and Analysis of Light-Responsive Circular RNA and Co-expression Networks in Lettuce (G3 (Bethesda, Md.) · 2020Article
- Epigenomic landscape and epigenetic regulation in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Review
- Identification and Characterization of circRNAs Responsive to Methyl Jasmonate inInternational journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circular RNAs (circRNAs) are a class of endogenous noncoding RNAs, which increasingly drawn researchers' attention in recent years as their importance in regulating gene expression at the transcriptional and post-transcriptional levels. With the development of high-throughput sequencing and bioinformatics, circRNAs have been widely analysed in animals, but the understanding of characteristics and function of circRNAs is limited in plants, especially in maize. Here, 3715 unique circRNAs were predicted in Zea mays systematically, and 8 of 12 circRNAs were validated by experiments. By analysing circRNA sequence, the events of alternative circularization phenomenon were found prevailed in maize. By comparing circRNAs in different species, it showed that part circRNAs are conserved across species, for example, there are 273 circRNAs conserved between maize and rice. Although most of the circRNAs have low expression levels, we found 149 differential expressed circRNAs responding to heat, cold, or drought, and 1782 tissue-specific expressed circRNAs. The results showed that those circRNAs may have potential biological functions in specific situations. Finally, two different methods were used to search circRNA functions, which were based on circRNAs originated from protein-coding genes and circRNAs as miRNA decoys. 346 circRNAs could act as miRNA decoys, which might modulate the effects of multiple molecular functions, including binding, catalytic activity, oxidoreductase activity, and transmembrane transporter activity. In summary, maize circRNAs were identified, classified and characterized systematically. We also explored circRNA functions, suggesting that circRNAs are involved in multiple molecular processes and play important roles in regulating of gene expression. Our results provide a rich resource for further study of maize circRNAs.
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